Hepatic interferon γ and tumor necrosis factor a expression in infants with neonatal cholestasis and cytomegalovirus infection.
Hepatic interferon γ and tumor necrosis factor a expression in infants with neonatal cholestasis and cytomegalovirus infection.
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DOI：
10.5114/ceh.2020.102172
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发表时间：
2020-12
影响因子：
1.5
通讯作者：
Shah I
中科院分区：
文献类型：
--
作者：
Meshram H;Velhal S;Padwal V;Sutar J;Kadam R;Pereira J;Bhonde G;Karandikar K;Bhor V;Patel V;Shetty NS;Shah I
目的探讨新生儿胆汁淤积症(NC)合并巨细胞病毒(CMV)感染时肝脏干扰素γ和肿瘤坏死因子γ(α-α)水平的变化。本研究在2017年6月至2017年12月期间对21例NC患儿进行了为期6个月的检测，以检测NC患儿及相关巨细胞病毒感染患儿的肝脏干扰素-γ和肿瘤坏死因子-α水平。干扰素-γ阳性16例(80%)，弱阳性3例(16%)，阴性1例(5%)。肝巨细胞病毒聚合酶链式反应阳性者9例(56.3%)，肿瘤坏死因子-α阳性者9例(56.3%)，弱阳性者7例(43.7%)(优势比[OR]=2.6)。肝巨细胞病毒γ阳性13例(81.3%)，弱阳性或阴性3例(18.7%)(OR=2.2)。6例(60%)肝组织肿瘤坏死因子-α阳性或高阳性的新生儿发生胆道闭锁，7例(77.7%)肝组织肿瘤坏死因子-α低阳性的新生儿发生非胆道闭锁(OR=5.2 5)。6例(37.5%)干扰素-γ阳性患者有BA，而2例(50%)干扰素-γ低阳性或阴性患者有BA(OR=0.6)。NC患者肝组织中巨细胞病毒感染率高，肿瘤坏死因子-α和干扰素-γ水平升高。BA患者中也可见肿瘤坏死因子-α升高。升高的肿瘤坏死因子-α、BA和巨细胞病毒感染之间的关系需要进一步评估。
To determine the hepatic interferon γ (IFN-γ) and tumor necrosis factor α (TNF-α) levels in infants with neonatal cholestasis (NC) and associated cytomegalovirus (CMV) infection. This study was conducted in 21 infants with NC over a period of 6 months from June 2017 to December 2017 to determine the hepatic IFN-γ and TNF-α levels in infants with NC and associated CMV infection. IFN-γ levels were positive in 16 (80%), low positive in 3 (16%) and negative in 1 (5%) patients. High positive and positive TNF-α levels were seen in 9 (56.3%) patients with positive liver CMV PCR and low positive levels were seen in 7 (43.7%) patients with positive liver CMV PCR (odds ratio [OR] = 2.6). Positive IFN-γ was present in 13 (81.3%) patients with positive liver CMV PCR and low positive or negative IFN-γ was seen in 3 (18.7%) patients with positive liver CMV PCR (OR = 2.2). Six (60%) patients with positive or high positive TNF-α levels in liver tissue had biliary atresia (BA) whereas 7 (77.7%) with low positive TNF-α levels had non-BA neonatal hepatitis (OR = 5.25). Six (37.5%) patients with positive IFN-γ had BA whereas 2 (50%) patients with low positive or negative IFN-γ had BA (OR = 0.6). There is high prevalence of CMV in liver tissues in patients with NC and elevated TNF-α and IFN-γ levels are seen in these patients. Elevated TNF-α is also seen in patients with BA. The association of elevated TNF-α, BA and CMV infection needs to be evaluated further.