Cognitive enhancers in the treatment of substance use disorders: clinical evidence.
Cognitive enhancers in the treatment of substance use disorders: clinical evidence.
复制标题
DOI：
10.1016/j.pbb.2011.04.017
复制
发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Tolliver BK
中科院分区：
文献类型：
--
作者：
Brady KT;Gray KM;Tolliver BK
迄今为止，药物奖赏的衰减一直是成瘾领域药物开发的主要焦点。随着认知神经科学领域研究的不断深入，执行功能和抑制性认知控制在成瘾性障碍中的重要性越来越明显。成瘾和其他精神疾病药物治疗的一个新兴策略涉及使用改善认知功能的药物。特别是，促进抑制和注意力控制，改善抽象，计划和精神灵活性的药物可能有利于治疗物质使用障碍。由于有多种神经递质系统参与认知功能的调节，因此已对许多药物类别的药物进行了测试。特别是，通过胆碱能、肾上腺素能和多巴胺能系统发挥作用的药物已显示出改善许多精神和神经疾病的认知功能的潜力，但这些药物中的大多数尚未在治疗物质使用障碍的个体中进行过测试。这份手稿提供了一个审查的临床数据，支持使用的主要类别的认知增强剂的物质使用障碍。还强调了在其他疾病中表现出认知增强前景的药物，以及应用于物质使用障碍的理论或机械原理。
Attenuation of drug reward has been the major focus of medication development in the addictions area to date. With the growth of research in the area of cognitive neuroscience, the importance of executive function and inhibitory cognitive control in addictive disorders is becoming increasingly apparent. An emerging strategy in the pharmacotherapy of addictions and other psychiatric disorders involves the use of medications that improve cognitive function. In particular, agents that facilitate inhibitory and attentional control, improve abstraction, planning and mental flexibility could be beneficial in the treatment of substance use disorders. Because there are multiple neurotransmitter systems involved in the regulation of cognitive function, agents from a number of drug classes have been tested. In particular, agents acting through the cholinergic, adrenergic and glutamatergic systems have shown potential for improving cognitive function in a number of psychiatric and neurologic disorders, but most of these agents have not been tested in the treatment of individuals with substance use disorders. This manuscript provides a review of clinical data supporting the use of the major classes of cognitive enhancing agents in substance use disorders. Agents that have shown promise in cognitive enhancement in other disorders, and have a theoretical or mechanistic rationale for application to substance use disorders are also highlighted.