Prevention of sudden cardiac death by dietary pure ω-3 polyunsaturated fatty acids in dogs
Prevention of sudden cardiac death by dietary pure ω-3 polyunsaturated fatty acids in dogs
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DOI：
10.1161/01.cir.99.18.2452
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发表时间：
1999-05-11
期刊：
影响因子：
37.8
通讯作者：
Leaf, A
中科院分区：
文献类型：
--
作者：
Billman, GE;Kang, JX;Leaf, A
研究背景：高鱼油含量的大鼠饮食已被证明对缺血诱导的致命性室性心律失常具有保护作用。越来越多的证据表明，这可能也适用于人类。为了在动物身上证实这一点，我们测试了一种浓缩的游离鱼油脂肪酸，发现它们具有抗糖尿病的作用。在这项研究中，我们测试了纯游离脂肪酸的2个主要的饮食ω-3多不饱和脂肪酸的鱼油：顺式-5，8，11，14，17-二十碳五烯酸（C20：5 ω-3）和顺式-4，7，10，13，16，19-二十二碳六烯酸（C22：6 ω-3），和父母ω-3脂肪酸在一些植物油，顺式-9，12，15-α-亚麻酸（C18：3 ω-3），静脉注射白蛋白或磷脂emulsifies.Methods和结果的测试进行了心脏性猝死的狗模型。用手术产生的大前壁心肌梗死和围绕左回旋冠状动脉放置的可充气袖带准备犬。手术后1个月，狗在跑步机上跑步，在试验前后1周进行的对照试验中，左回旋支动脉的闭塞定期产生心室纤颤，ω-3脂肪酸以其纯游离脂肪酸的形式静脉内施用。静脉注射二十碳五烯酸后，7只犬中有5只可避免致命性室性心律失常（P
Background-Rat diets high in fish oil have been shown to be protective against ischemia-induced fatal ventricular arrhythmias. Increasing evidence suggests that this may also apply to humans. To confirm the evidence in animals, we tested a concentrate of the free fish-oil fatty acids and found them to be antiarrhythmic. In this study, we tested the pure free fatty acids of the 2 major dietary omega-3 polyunsaturated fatty acids in fish oil: cis-5,8,11,14,17-eicosapentaenoic acid (C20:5 omega-3) and cis-4,7,10,13,16, 19-docosahexaenoic acid (C22:6 omega-3), and the parent omega-3 fatty acid in some vegetable oils, cis-9,12,15-alpha-linolenic acid (C18:3 omega-3), administered intravenously on albumin or a phospholipid emulsion.Methods and Results-The tests were performed in a dog model of cardiac sudden death. Dogs were prepared with a large anterior wall myocardial infarction produced surgically and an inflatable cuff placed around the left circumflex coronary artery. With the dogs running on a treadmill 1 month after the surgery, occlusion of the left circumflex artery regularly produced ventricular fibrillation in the control tests done 1 week before and after the test, with the omega-3 fatty acids administered intravenously as their pure free fatty acid. With infusion of the eicosapentaenoic acid, 5 of 7 dogs were protected from fatal ventricular arrhythmias (P