Ureaplasma urealyticum infection of the placenta in pregnancies that ended prematurely
Ureaplasma urealyticum infection of the placenta in pregnancies that ended prematurely
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DOI：
10.1016/0029-7844(95)00376-2
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发表时间：
1996-01-01
影响因子：
7.2
通讯作者：
Pollin, SA
中科院分区：
文献类型：
--
作者：
Kundsin, RB;Leviton, A;Pollin, SA
目的：探讨胎盘解脲支原体感染与早产的关系。方法：我们研究了647例孕妇，导致活产婴儿体重小于1501克。胎盘绒毛膜表面培养解脲脲原体、人型支原体和B组链球菌。结果：解脲脲原体分离率随破膜与分娩间隔时间的增加而增加。当分析仅限于96例在胎膜破裂1小时内和妊娠29周前结束的单胎妊娠时，解脲脲原体与早产发生风险增加显著相关（未校正P = 0.008，校正所有潜在混杂因素后P = 0.05）。支原体感染率是最低的妊娠终止，因为严重的母亲先兆子痫或进行性胎儿生长受限。结论：解脲支原体感染与早产发生的劳动力和持续时间增加之间的破膜和交付。应考虑从女性及其伴侣的泌尿生殖道根除支原体，最好在受孕前。
Objective: To investigate the relationship between Urea-plasma urealyticum infection of the placenta and premature onset of labor.Methods: We studied 647 pregnancies that resulted in the live birth of an infant weighing less than 1501 g. The chorionic surface of the placenta was cultured for U urea-lyticum, Mycoplasma hominis, and group B streptococci.Results: The rate of ureaplasma isolation increased with increasing interval between rupture of membranes and delivery. When analyses were limited to the 96 singleton pregnancies that ended within 1 hour of rupture of membranes and before the 29th week of gestation, U urealyticum was prominently associated with an increased risk of premature onset of labor (P =.008 unadjusted, and P =.05 when adjustment was made for all potential confounders). Ureaplasma infection rate was lowest in pregnancies terminated because of severe maternal preeclampsia or progressive fetal growth restriction.Conclusion: Ureaplasma urealyticum infection is associated with premature onset of labor and with increasing duration of time between rupture of membranes and delivery. Eradication of ureaplasmas from the urogenital tract of women and their partners, ideally before conception, should be considered.