Development of nonstick and drug-loaded wound dressing based on the hydrolytic hydrophobic poly(carboxybetaine) ester analogue.
Development of nonstick and drug-loaded wound dressing based on the hydrolytic hydrophobic poly(carboxybetaine) ester analogue.
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DOI：
10.1021/am403657t
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发表时间：
2013-10
影响因子：
9.5
通讯作者：
Fangqin Ji;Weifeng Lin;Zhen Wang;Longgang Wang;Juan Zhang;Guanglong Ma;Shengfu Chen
中科院分区：
文献类型：
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作者：
Fangqin Ji;Weifeng Lin;Zhen Wang;Longgang Wang;Juan Zhang;Guanglong Ma;Shengfu Chen
研制了一种用于创面敷料抗菌不粘涂层的新型生物相容性聚合物。该聚合物由羧基甜菜碱酯类似物甲基丙烯酸酯(CB-ESTER)和小分子聚乙二醇甲基丙烯酸酯(PEGMA)共聚而成，以六亚甲基二异氰酸酯(HDI)为交联剂，具有良好的抗非特异性蛋白质吸附和快速水解后的哺乳动物细胞附着能力。一种小的疏水药物阿司匹林可以被结合到新的聚合物中并缓慢释放，以抑制微生物的生长，而新的聚合物显示出非常低的细胞毒性。此外，新型聚合物涂层医用纱布创面敷料具有良好的力学性能，如柔韧性和强度，用于医用。毕竟，这种新型的无污染聚合物为抗菌伤口敷料和其他应用提供了巨大的潜力。
A novel biocompatible polymer is developed for antimicrobial and nonstick coatings of wound dressing. The polymer is formed by copolymerization of carboxybetaine ester analogue methacrylate (CB-ester) and small partial poly(ethylene glycol) methacrylate (PEGMA) for cross-linking by hexamethylene diisocyanate (HDI), which is highly resistant to nonspecific protein adsorption and mammalian cell attachment after a quick hydrolysis. A small hydrophobic drug, aspirin, can be incorporated into the new polymer and slowly released to inhibit microorganism growth while the new polymer shows very low cytotoxicity. Moreover, the wound dressing, the new polymer coated medical gauze, shows good mechanic properties, such as flexibility and strength, for medical application. After all, this new nonfouling polymer offers great potential for an antimicrobial wound dressing and other applications.