Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene
Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene
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DOI：
10.1126/science.1083968
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发表时间：
2003-07-18
期刊：
影响因子：
56.9
通讯作者：
Poulton, R
中科院分区：
文献类型：
--
作者：
Caspi, A;Sugden, K;Poulton, R
在一项针对代表性出生队列的前瞻性纵向研究中，我们测试了为什么压力经历会导致某些人抑郁，而另一些人则不会。研究发现，血清素转运蛋白（5-HTT）基因启动子区的功能多态性可以减轻压力生活事件对抑郁症的影响。与长等位基因纯合子的个体相比，具有一个或两个 5-HTT 启动子多态性短等位基因拷贝的个体表现出更多的抑郁症状、可诊断的抑郁症和与压力生活事件相关的自杀倾向。因此，这项流行病学研究提供了基因与环境相互作用的证据，其中个体对环境侮辱的反应是由他或她的基因构成调节的。
In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others. A functional polymorphism in the promoter region of the serotonin transporter (5-HTT) gene was found to moderate the influence of stressful life events on depression. Individuals with one or two copies of the short allele of the 5-HTT promoter polymorphism exhibited more depressive symptoms, diagnosable depression, and suicidality in relation to stressful life events than individuals homozygous for the long allele. This epidemiological study thus provides evidence of a gene-by-environment interaction, in which an individual's response to environmental insults is moderated by his or her genetic makeup.