Interferons in Autoimmune and Inflammatory Diseases: Regulation and Roles
Interferons in Autoimmune and Inflammatory Diseases: Regulation and Roles
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DOI：
10.1089/jir.2011.0101
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发表时间：
2011-12-01
影响因子：
2.3
通讯作者：
Moudgil, Kamal D.
中科院分区：
文献类型：
--
作者：
Choubey, Divaker;Moudgil, Kamal D.
一些证据强烈暗示I型干扰素（IFN-α和β）和IFN-信号传导在某些自身免疫性炎性疾病的发病机制中。因此，全基因组关联研究已经鉴定了I型IFN信号通路中的多态性。其他研究也表明，一个前馈回路的I型干扰素生产，其中涉及传感器的细胞质核酸的传感，有助于免疫病理学的发展。此外，I型干扰素和雌激素受体-α之间的相互积极的调节反馈回路可能有助于性别偏见，从而导致妇女I型干扰素的产生增加和相关的免疫病理学。I型IFN水平的增加对先天性和适应性免疫应答具有多种免疫调节功能。鉴于IFN-β也具有一定的抗炎作用，识别自身免疫性炎症性疾病患者中某些基因型、细胞因子谱和相关表型之间的分子联系可能会提高我们对自身免疫相关发病机制和标准治疗后次优结局的理解。
Several lines of evidence strongly implicate type I interferons (IFN-alpha and beta) and IFN-signaling in the pathogenesis of certain autoimmune inflammatory diseases. Accordingly, genome-wide association studies have identified polymorphisms in the type I IFN-signaling pathways. Other studies also indicate that a feed-forward loop of type I IFN production, which involves sensing of cytoplasmic nucleic acids by sensors, contributes to the development of immunopathology. In addition, a mutually positive regulatory feedback loop between type I IFNs and estrogen receptor-alpha may contribute to a gender bias, thus resulting in an increased production of type I IFNs and associated immunopathology in women. Increased levels of type I IFNs have numerous immunomodulatory functions for both the innate and adaptive immune responses. Given that the IFN-beta also has some anti-inflammatory roles, identifying molecular links among certain genotypes, cytokine profiles, and associated phenotypes in patients with autoimmune inflammatory diseases is likely to improve our understanding of autoimmunity-associated pathogenesis and suboptimal outcomes following standard therapies.