Genetic heterogeneity of oesophageal cancer in high-incidence areas of southern and northern China.
Genetic heterogeneity of oesophageal cancer in high-incidence areas of southern and northern China.
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中国南北方食管癌高发区的遗传异质性.
DOI：
10.1371/journal.pone.0009668
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发表时间：
2010-03-15
期刊：
影响因子：
3.7
通讯作者：
Yuxia G
中科院分区：
文献类型：
--
作者：
Guohong Z;Min S;Duenmei W;Songnian H;Min L;Jinsong L;Hongbin L;Feng Z;Dongping T;Heling Y;Zhicai L;Shiyong L;Quansheng G;Xiaoyun L;Yuxia G
食道癌是世界上最常见和最致命的癌症之一。我们之前的人群研究报告了广东省潮汕市食道癌的高发情况，中国说。潮汕人的祖先是从中国中北部的太行山区迁徙而来的，太行山区是食道癌的另一个高发区。本研究的目的是以太行山人群为参照，获得潮州人群食道癌遗传易感性的证据，最终目的是对食道癌基因进行分子鉴定。应用S.A.G.E.Version 5.3.0中的FPMM程序对潮汕地区224个家系和太行地区403个家系进行了家系相关、混合和复合分离分析。第二个分析集中在有大量受影响个人或疾病发病较早的特定家庭。在普通人群中，食道癌存在中等的同胞-同胞相关性。此外，兄弟间的相关性更高。混合分析表明，三组分分布模型最好地解释了食道癌发病年龄的差异，而多因素模型提供了对总体人口数据的最好拟合。常染色体显性遗传模式和显性或隐性主效基因多基因遗传是食道癌遗传易感性的最佳模式。本研究结果为中国地区某些高危人群中食道癌的遗传易感性提供了证据，并为寻找易感基因提供了依据。
Oesophageal cancer is one of the most common and deadliest cancers worldwide. Our previous population-based study reported a high prevalence of oesophageal cancer in Chaoshan, Guangdong Province, China. Ancestors of the Chaoshan population migrated from the Taihang Mountain region of north-central China, which is another high-incidence area for oesophageal cancer. The purpose of the present study was to obtain evidence of inherited susceptibility to oesophageal cancer in the Chaoshan population, with reference to the Taihang Mountain population, with the eventual goal of molecular identification of the disease genes. We conducted familial correlation, commingling, and complex segregation analyses of 224 families from the Chaoshan population and 403 families from the Taihang population using the FPMM program of S.A.G.E. version 5.3.0. A second analysis focused on specific families having large numbers of affected individuals or early onset of the disease. For the general population, moderate sib-sib correlation was noticed for esophageal cancer. Additionally, brother-brother correlation was even higher. Commingling analyses indicated that a three-component distribution model best accounts for the variation in age of onset of oesophageal cancer, and that a multifactorial model provides the best fit to the general population data. An autosomal dominant mode and a dominant or recessive major gene with polygenic inheritance were found to be the best models of inherited susceptibility to oesophageal cancer in some large families. The current results provide evidence for inherited susceptibility to oesophageal cancer in certain high-risk groups in China, and support efforts to identify the susceptibility genes.