Effects of Proton Pump Inhibitors in Patients with Laryngopharyngeal Reflux Disease
Effects of Proton Pump Inhibitors in Patients with Laryngopharyngeal Reflux Disease
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DOI：
10.5754/hge09607
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发表时间：
2011-09-01
影响因子：
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通讯作者：
Sato, Hiroaki
中科院分区：
文献类型：
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作者：
Chiba, Toshimi;Kudara, Norihiko;Sato, Hiroaki
背景/目的：质子泵抑制剂（PPIs）对喉咽反流病（LPRD）患者健康相关生活质量（HRQoL）的影响尚不清楚。我们的目的是评估LPRD患者服用PPI前后的HRQoL。方法：共纳入27例LPRD患者（女性14例，男性13例，平均年龄54岁）。我们使用三种不同的询问系统来确定HRQoL: 1)胃食管反流症状频率量表（FSSG）；2)医学结局研究问卷（SF-36） 36项简表；3)胃肠症状评定量表（GSRS）。HRQoL是在基线和8周后用兰索拉唑30mg每日一次或雷贝拉唑10mg每日一次治疗后测定的。结果：PPI给药后，FSSG、SF-36一般健康量表和心理健康量表、GSRS反流综合征评分、腹痛综合征评分和消化不良综合征评分较治疗前基线评分均有显著改善(p
Background/Aims: The effect of proton pump inhibitors (PPIs) on the health-related quality of life (HRQoL) of patients with laryngopharyngeal reflux disease (LPRD) is not well known. Our aim was to assess the HRQoL before and after administration of a PPI in patients with LPRD.Methodology: A total of 27 LPRD patients (14 women, 13 men; mean age 54 years) were enrolled. We determined the HRQoL using three different inquiry systems: 1) Frequency Scale for the Symptoms of GERD (FSSG); 2) the 36 item short form of the Medical Outcome Study Questionnaire (SF-36); and 3) the Gastrointestinal Symptom Rating Scale (GSRS). The HRQoL was determined at baseline and after eight weeks of treatment with lansoprazole at a dose of 30mg once daily or rabeprazole at a dose of 10mg once daily.Results: After administration of the PPI, the FSSG, the SF-36 general health scale and mental health scale, GSRS reflux syndrome score, abdominal pain syndrome score and the indigestion syndrome score were significantly improved compared to baseline pretreatment scores (p