Peripheral ghrelin reduces food intake and respiratory quotient in chicken
Peripheral ghrelin reduces food intake and respiratory quotient in chicken
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DOI：
10.1016/j.domaniend.2005.06.005
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发表时间：
2006-02-01
影响因子：
2.1
通讯作者：
Darras, VM
中科院分区：
文献类型：
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作者：
Geelissen, SME;Swennen, Q;Darras, VM
Ghrelin注射，无论是中枢或外周强烈刺激人类和啮齿动物的摄食。相比之下，中枢注射ghrelin抑制新生鸡的食物摄入。关于这一机制及其与鸡体内能量平衡的关系，目前尚无相关信息。由于生长素释放肽主要是在胃中产生的，我们研究了外周注射生长素释放肽（1纳摩尔/100克体重）对食物摄入量和能量消耗的影响，通过间接量热法在一周龄鸡的呼吸细胞中测量24小时。在单独的实验中测量血糖、甘油三酯、游离脂肪酸、总蛋白和T-3，直至注射后60 min。食物摄入减少，直到静脉内胃饥饿素给药后至少1小时。注射生长激素释放肽的鸡的呼吸商（RQ）降低，直到14小时后给药，而血浆葡萄糖和甘油三酯浓度没有改变。游离脂肪酸和总蛋白水平也保持不变。Ghrelin没有影响产热，这是支持的血浆T3水平的变化的情况下相比，控制values.In结论，外周Ghrelin减少食物摄入量以及RQ和可能会影响的类型的基板（常量营养素），被用作代谢燃料。(c)2005年爱思唯尔公司All rights reserved.
Ghrelin injection, either centrally or peripherally strongly stimulates feeding in human and rodents. In contrast, centrally injected ghrelin inhibits food intake in neonatal chickens. No information is available about the mechanism and its relationship with energy homeostasis in chicken. Since ghrelin is predominantly produced in the stomach, we investigated the effect of peripherally injected ghrelin (1 nmol/100g body weight) on food intake and energy expenditure as measured in respiratory cells by indirect calorimetry for 24 h in one-week-old chickens. Plasma glucose, triglycerides, free fatty acids, total protein and T-3 were measured in a separate experiment until 60 min after injection. Food intake decreased until at least I h after intravenous ghrelin administration. The respiratory quotient (RQ) in ghrelin-injected chickens was reduced until 14h after administration whereas plasma glucose and triglycerides concentrations were not altered. Free fatty acids and total protein levels also remained unchanged. Ghrelin did not influence heat production and this was supported by the absence of changes in plasma T3 levels when compared to the control values.In conclusion, peripheral ghrelin reduces food intake as well as RQ and might influence the type of substrate (macronutrient) that is used as metabolic fuel. (c) 2005 Elsevier Inc. All rights reserved.