Correlation between clinical outcome and size and site of the lesion in computed tomography guided thalamotomy and pallidotomy.
Correlation between clinical outcome and size and site of the lesion in computed tomography guided thalamotomy and pallidotomy.
复制标题
计算机断层扫描引导的丘脑切开术和苍白球切开术中临床结果与病变大小和部位之间的相关性。
DOI：
10.1159/000100210
复制
发表时间：
1990
影响因子：
1.7
通讯作者：
M. Hariz
中科院分区：
文献类型：
--
作者：
M. Hariz
19例遗传性震颤或帕金森病患者接受了14例丘脑切开术和5例苍白球切开术。使用Laitinen无创立体适配器通过立体定位计算机断层扫描研究确定靶点坐标。手术未进行脑室造影。3-12个月后对患者进行评估。在术后立体定向计算机断层扫描研究中，标记丘脑和苍白球靶点的位置，并测量病变中心相对于这些靶点的坐标。计算病灶体积。丘脑病变3例，未见病变。11例可见丘脑病变的大小范围为4 ~ 75 mm 3（平均26），5例苍白球病变的大小范围为28 ~ 150 mm 3（平均67）。平均而言，病变中心位于解剖靶位置内侧1.4 mm处（p <0.002）。病变的大小和部位与临床结果无关。
Fourteen thalamotomies and five pallidotomies were performed in 19 patients with hereditary intention tremor or Parkinson's disease. The target coordinates were determined by a stereotactic computed tomography study using the Laitinen noninvasive stereoadapter. Surgery was done without ventriculography. The patients were assessed 3-12 months later. In a postoperative stereotactic computed tomography study, the positions of the thalamic and pallidal targets were marked, and the coordinates of the center of the lesion were measured in relation to these targets. The volume of the lesion was calculated. In 3 thalamic lesion patients, no lesion could be visualized. The size of the eleven visible thalamic lesions ranged from 4 to 75 mm3 (mean 26), and the size of the 5 pallidal lesions ranged from 28 to 150 mm3 (mean 67). On the average, the center of the lesion was 1.4 mm medial to the position of the anatomical target (p less than 0.002). Neither size nor site of the lesion correlated with the clinical outcome.