Rotavirus genotype and Vesikari score of outpatients in Japan in the vaccine era.
Rotavirus genotype and Vesikari score of outpatients in Japan in the vaccine era.
复制标题
疫苗时代日本门诊患者轮状病毒基因型及Vesikari评分
DOI：
10.1111/ped.14150
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Kawasaki Y.
中科院分区：
文献类型：
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作者：
Ono M;Tsugawa T;Nakata S;Kondo K;Tatsumi M;Tsutsumi H;Kawasaki Y.
背景A组轮状病毒（RV）是婴幼儿严重胃肠炎的主要原因。在日本，RV疫苗于2011年引入，导致严重胃肠炎病例减少。研究需要评估疫苗的有效性及其对RV genotype.MethodsFecal流行的影响，收集从RV胃肠炎在儿科诊所在札幌，日本，从2010年至2016年的门诊患者。使用逆转录聚合酶链反应测定GPI基因型。从2013年以后的门诊患者中获得临床信息和免疫记录。GPI基因型和临床特征进行了比较，患者和没有RV疫苗history.ResultsIn的，共270例基因分型。G1 P [8]I1（Wa‐like G1 P [8]）菌株在2010年至2012年期间占主导地位。G1 P [8]I2（DS-1-like G1 P [8]）菌株出现于2012年，并在2013年至2015年占主导地位。G2 P [4]I2和G9 P [8]I1菌株每3年增加一次（G2 P [4]I2：2011和2014，G9 P [8]I1：2010、2013和2016）。2013年流感季后，收集了137例病例，其中24例接种了疫苗。疫苗接种组需要滴注的病例少于非疫苗接种组（16.7% vs 52.2%）。疫苗接种组中没有患者需要住院，而非疫苗接种组中有10.6%的患者需要住院。接种组中重度Vesikari评分的发生率低于未接种组（33.3% vs 78.8%）。两组GPI基因型分布无显著差异。结论轮状病毒疫苗的有效性，无论GPI基因型，证实在缓解疾病的严重程度。
BackgroundGroup A rotaviruses (RVs) are a major cause of severe gastroenteritis among infants and young children. In Japan, RV vaccines were introduced in 2011, leading to a reduction in severe gastroenteritis cases. Studies are required to assess the effectiveness of the vaccines and their effect on the prevalence of RV genotypes.MethodsFecal samples were collected from outpatients with RV gastroenteritis in a pediatric clinic in Sapporo, Japan, from 2010 to 2016. GPI genotypes were determined using reverse‐transcription polymerase chain reaction. Clinical information and immunization records were obtained from outpatients after 2013. GPI genotypes and clinical features were compared between patients with and without a RV vaccine history.ResultsIn total, 270 cases were genotyped. G1P[8]I1 (Wa‐like G1P[8]) strains were dominant from 2010 to 2012. G1P[8]I2 (DS‐1‐like G1P[8]) strains appeared in 2012 and dominated in 2013 to 2015. G2P[4]I2 and G9P[8]I1 strains increased every 3 years (G2P[4]I2: 2011 and 2014, G9P[8]I1: 2010, 2013 and 2016). After the 2013 season, 137 cases were collected, 24 of which were vaccinated. Cases requiring drip infusion were fewer in the vaccination group than in the non‐vaccination group (16.7% vs 52.2%). No patients required hospitalization in the vaccination group compared with 10.6% in the non‐vaccination group. A severe Vesikari score was less common in the vaccination group than in the non‐vaccination group (33.3% vs 78.8%). There was no significant difference in the GPI genotype distribution between the two groups.ConclusionRotaviruses vaccine effectiveness, regardless of GPI genotype, was confirmed in terms of alleviation of disease severity.