Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: A cohort analysis of 2.7M people
Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: A cohort analysis of 2.7M people
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通过疫苗接种状态、既往感染和邻里剥夺，通过 Delta 波和 Omicron 波改变 SARS-CoV-2 感染模式：对 270 万人进行的队列分析
DOI：
10.1101/2022.04.05.22273169
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Green M
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文献类型：
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作者：
Green M
背景我们的研究检查SARS-CoV-2感染是否因疫苗接种状态而变化，如果个体先前检测为阳性，以及在SARS-CoV-2.MethodsPopulation cohort study中，使用柴郡和默西塞德郡270万居民的电子健康记录，英格兰（2021年6月3日至2022年3月1日）的Delta和Omicron流行波的社区社会经济剥夺。我们的结果变量是登记的SARS-CoV-2检测阳性。解释变量为疫苗接种状况、既往登记阳性检测和社区社会经济剥夺。考克斯回归模型被用来分析association.ResultsOriginally较高的SARS-CoV-2率在社会经济上最贫困的社区改变为更高的最贫困的社区从2021年9月1日，并在Omicron波不一致。完全接种疫苗（两剂）的个体与较少的登记阳性检测相关（例如，在2021年9月1日至11月27日期间参与测试的个人-风险比（HR）= 0.48，95%置信区间（CI）= 0.47-0.50。先前登记阳性测试的个体也不太可能有登记阳性测试（例如，在2021年9月1日至11月27日期间参与测试的个体-HR = 0.16，95% CI = 0.15-0.18。然而，Omicron期间看到了较小的效果大小的疫苗接种状态和以前登记的阳性test.ConclusionsChanging模式的SARS-CoV-2感染在三角洲和Omicron波揭示了一个动态的大流行，继续影响不同的社区，有时意想不到的方式。
BackgroundOur study examines if SARS-CoV-2 infections varied by vaccination status, if an individual had previously tested positive and by neighbourhood socioeconomic deprivation across the Delta and Omicron epidemic waves of SARS-CoV-2.MethodsPopulation cohort study using electronic health records for 2.7 M residents in Cheshire and Merseyside, England (3rd June 2021 to 1st March 2022). Our outcome variable was registered positive test for SARS-CoV-2. Explanatory variables were vaccination status, previous registered positive test and neighbourhood socioeconomic deprivation. Cox regression models were used to analyse associations.ResultsOriginally higher SARS-CoV-2 rates in the most socioeconomically deprived neighbourhoods changed to being higher in the least deprived neighbourhoods from the 1st September 2021, and were inconsistent during the Omicron wave. Individuals who were fully vaccinated (two doses) were associated with fewer registered positive tests (e.g., individuals engaged in testing between 1st September and 27th November 2021—Hazards Ratio (HR) = 0.48, 95% Confidence Intervals (CIs) = 0.47–0.50. Individuals with a previous registered positive test were also less likely to have a registered positive test (e.g., individuals engaged in testing between 1st September and 27th November 2021—HR = 0.16, 95% CIs = 0.15–0.18. However, the Omicron period saw smaller effect sizes for both vaccination status and previous registered positive test.ConclusionsChanging patterns of SARS-CoV-2 infections during the Delta and Omicron waves reveals a dynamic pandemic that continues to affect diverse communities in sometimes unexpected ways.