Proton magnetic resonance spectroscopy: normal findings in the cerebellar hemisphere in childhood
Proton magnetic resonance spectroscopy: normal findings in the cerebellar hemisphere in childhood
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DOI：
10.1007/s00247-002-0777-5
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发表时间：
2002-11-01
影响因子：
2.3
通讯作者：
Leite, CD
中科院分区：
文献类型：
--
作者：
Costa, MOR;Lacerda, MTC;Leite, CD
背景：小脑半球（CER）与幕上白质和灰质在胚胎学上、细胞结构上以及可能在代谢活性上都不同。质子磁共振波谱（H-1 MRS）可以提供该区域的无创生化分析。目的：利用H-1 MRS研究CER代谢物浓度与年龄的关系，并与健康儿童顶枕白质（PO WM）代谢物浓度进行比较。材料和方法：采用单体素H-1 MRS对37名3-18岁的志愿者进行正常脑MRI扫描。在CER和PO WM中采用PRESS技术进行H-1 MRS。分析NAA/Cr、Cho/Cr、NAA/H2O、Cr/H2O、Cho/H2O随年龄的变化规律。比较了这些区域的代谢数据。结果：CER中NAA/Cr随年龄的增长呈上升趋势。平均NAA/Cr和Cho/Cr比值在CER组低于PO WM组。平均NAA/H2O、Cr/ H2O和Cho/H2O比值在CER中高于PO WM。结论：我们的数据证实了CER和PO WM代谢物比率之间的区域差异，并显示了CER中NAA/ Cr比率的年龄依赖性变化趋势。小脑肌酸浓度显著高于大鼠脑肌酸浓度。
Background: The cerebellar hemispheres (CER) are different from the supratentorial white and gray matter embryologically, in cytoarchitecture, and probably in metabolic activity. Proton magnetic resonance spectroscopy (H-1 MRS) can provide a noninvasive biochemical analysis of this region. Objective: To study, with H-1 MRS, metabolite concentrations in CER as a function of age and compare these metabolic data with those of parietoccipital white matter (PO WM) in healthy children. Materials and methods: Using single-voxel H-1 MRS, we studied 37 volunteers (3-18 years) with normal MRI scans of the brain. H-1 MRS was performed using the PRESS technique in CER and PO WM. The NAA/Cr, Cho/Cr, NAA/H2O, Cr/H2O, and Cho/H2O ratios were analyzed as a function of age. Metabolic data from these regions were compared. Results: The NAA/Cr ratio tended to increase with age in CER. Mean NAA/Cr and Cho/Cr ratios were found to be lower in CER than in PO WM. Mean NAA/H2O, Cr/ H2O, and Cho/H2O ratios in CER were higher than in the PO WM. Conclusion: Our data confirm the regional variations between CER and PO WM metabolite ratios, and demonstrate a tendency of age-dependent change of the NAA/ Cr ratio in CER. The creatine concentration was significantly higher in the cerebellum than in the PO WM.