Chitosan membrane as a template for hydroxyapatite crystal growth in a model dual membrane diffusion system
Chitosan membrane as a template for hydroxyapatite crystal growth in a model dual membrane diffusion system
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DOI：
10.1016/j.memsci.2005.11.050
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发表时间：
2006-03-31
影响因子：
9.5
通讯作者：
Worch, H
中科院分区：
文献类型：
--
作者：
Ehrlich, H;Krajewska, B;Worch, H
壳聚糖作为一种生物相容性、生物可降解性和生物活性材料，以膜的形式作为体外矿化过程的基质提供了巨大的潜力。在双膜扩散系统中，研究了磷酸钙相在凝胶壳聚糖膜上的晶体生长。在该系统中，阳离子和阴离子选择性膜用于控制Ca 2+和PO 43-离子扩散以产生过饱和反应条件。我们首次表明，该系统可以成功地用于定向晶体生长和定性控制磷酸钙相在壳聚糖基质中的仿生模式。矿化壳聚糖在骨组织修复和再生方面具有潜在的应用价值。(c)2005 Elsevier B. V.保留所有权利。
Being a biocompatible, biodegradable and bioactive material, chitosan in the form of membranes offers a great potential as a substrate in mineralization processes in vitro. In the present work, the crystal growth of calcium phosphate phases on gel chitosan membranes was studied in the dual membrane diffusion system. In the system cation- and anion-selective membranes are used to control Ca2+ and PO43- ionic diffusion to generate supersaturation reaction conditions. We show for the first time that the system can be successfully used for oriented crystal growth and for qualitative control of calcium phosphate phases on chitosan matrices in a biomimetic mode. The mineralized chitosan can be potentially applied in bone tissue repair and regeneration. (c) 2005 Elsevier B.V. All rights reserved.