Resistance selection of indoxacarb in Helicoverpa armigera (Hubner) (Lepidoptera: Noctuidae): cross-resistance, biochemical mechanisms and associated fitness costs
Resistance selection of indoxacarb in Helicoverpa armigera (Hubner) (Lepidoptera: Noctuidae): cross-resistance, biochemical mechanisms and associated fitness costs
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棉铃虫茚虫威的抗性选择。
DOI：
10.1002/ps.5056
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发表时间：
2018-11-01
影响因子：
4.1
通讯作者：
Rui, Changhui
中科院分区：
文献类型：
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作者：
Cui, Li;Wang, Qinqin;Rui, Changhui
背景：棉铃虫是一种世界性的害虫，对多种杀虫剂具有抗药性。茚虫威是一种钠离子通道阻滞剂，是一种重要的杀虫剂，用于防治H。armigera。建立了茚虫威选择的红腹小球藻（IND-SEL）种群的交互抗性、代谢机制和生活史特征。armigera.RESULTS:经11代选择后，对茚虫威的敏感性下降了4.43倍，估计的实现遗传力（h（2））仅为0.072。有趣的是，IND-SEL种群比易感种群对甲氧虫酰肼和阿维菌素更敏感。细胞色素P450单加氧酶（P450）和羧酸酯酶（CarE）活性显著升高。armigera。因此，茚虫威的敏感性增加胡椒基丁醚和S，S，S-三丁基硫代磷酸酯，显示协同比分别为2.54和1.82倍。此外，IND-SEL人口有一个减少的相对适合度（0.67），具有较低的增长率和繁殖力比易感population.CONCLUSIONS：这项研究的证据表明，降低茚虫威的敏感性可能与健身成本在H。P450和CarE活性的增强可能是棉铃虫抗药性产生的重要解毒机制。甲氧虫酰肼和阿维菌素可轮换使用，以管理茚虫威抗性。(C)2018年化学工业协会
BACKGROUND: The cotton bollworm Helicoverpa armigera is a worldwide insect pest with the ability to develop resistance to many insecticides. Indoxacarb, a sodium channel blocker, is an important insecticide that is used to control H. armigera. Cross-resistance, metabolic mechanisms and life history traits were established for an indoxacarb-selected (IND-SEL) population of H. armigera.RESULTS: After 11 generations of selection, the susceptibility to indoxacarb was decreased by 4.43-fold and the estimated realized heritability (h(2)) was only 0.072. Interestingly, the IND-SEL population was more susceptible to methoxyfenozide and abamectin than the susceptible population. The activities of cytochrome P450 monooxygenase (P450) and carboxyl esterase (CarE) were significantly increased in IND-SEL H. armigera. Thus, susceptibility to indoxacarb was increased by piperonyl butoxide and S,S,S-tributyl phosphorothioate, showing synergistic ratios of 2.54- and 1.82-fold, respectively. Moreover, the IND-SEL population had a reduced relative fitness (0.67), with a lower growth rate and fecundity than the susceptible population.CONCLUSIONS: Evidence from this study suggests that decreased susceptibility to indoxacarb may be associated with fitness costs in H. armigera and enhanced activities of P450 and CarE may be important detoxification mechanisms in the development of indoxacarb resistance. Methoxyfenozide and abamectin can be rotationally used to manage indoxacarb resistance. (C) 2018 Society of Chemical Industry