A concise total synthesis of cochlearoid B
A concise total synthesis of cochlearoid B
复制标题
耳蜗B的简明全合成
DOI：
10.1039/c8ob00615f
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发表时间：
2018
影响因子：
3.2
通讯作者：
Wang Bo
中科院分区：
文献类型：
--
作者：
Zhang Wuxia;Xiao Dehai;Wang Bo
A T-type calcium channel inhibiting natural product cochlearoid B was synthesized for the first time in 7 linear steps via a convergent strategy exploiting the Suzuki–Miyaura cross coupling and the acid promoted Prins cyclization cascade. This strategy allows rapid access to its structural analogues for further therapeutical development.
