Rapid prototyping of microfluidic systems using a PDMS/polymer tape composite
Rapid prototyping of microfluidic systems using a PDMS/polymer tape composite
复制标题
DOI：
10.1039/b818389a
复制
发表时间：
2009-01-01
期刊：
影响因子：
6.1
通讯作者：
Gale, Bruce K.
中科院分区：
文献类型：
--
作者：
Kim, Jungkyu;Surapaneni, Rajesh;Gale, Bruce K.
介绍了一种利用双面胶带和聚二甲基硅氧烷（PDMS）相结合的微流控系统快速成型方法。由于PDMS的疏水性质和低表面能，其通常难以使用胶带粘合。出于这个原因，PDMS与xurography方法不兼容，xurography方法使用刀和各种粘合剂涂覆的聚合物胶带。为了解决这些问题，PDMS/胶带复合材料的开发和演示在微流体应用。PDMS/胶带复合材料是通过将其旋转以在双面胶带上形成一薄层PDMS而形成的。然后使用Xurography对PDMS/胶带复合材料进行图案化以创建通道，并粘合到PDMS板上。从胶带上取下背纸后，可以通过将结构放置在几乎任何基底上来创建完整的微流体系统;包括玻璃，塑料或金属涂层的玻璃/硅基底。结合强度被证明是足够的压力，发生在典型的微流体通道用于化学或生物分析。该方法在三个应用中得到了证实：标准微流体通道和反应器，具有集成膜的微流体系统和电化学生物传感器。PDMS/带复合材料快速原型技术提供了一种快速且成本有效的制造方法，并且可以提供微流体通道与传感器和其他部件的容易集成，而不需要洁净室设施。
Rapid prototyping of microfluidic systems using a combination of double-sided tape and PDMS (polydimethylsiloxane) is introduced. PDMS is typically difficult to bond using adhesive tapes due to its hydrophobic nature and low surface energy. For this reason, PDMS is not compatible with the xurography method, which uses a knife plotter and various adhesive coated polymer tapes. To solve these problems, a PDMS/tape composite was developed and demonstrated in microfluidic applications. The PDMS/tape composite was created by spinning it to make a thin layer of PDMS over double-sided tape. Then the PDMS/tape composite was patterned to create channels using xurography, and bonded to a PDMS slab. After removing the backing paper from the tape, a complete microfluidic system could be created by placing the construct onto nearly any substrate; including glass, plastic or metal-coated glass/silicon substrates. The bond strength was shown to be sufficient for the pressures that occur in typical microfluidic channels used for chemical or biological analysis. This method was demonstrated in three applications: standard microfluidic channels and reactors, a microfluidic system with an integrated membrane, and an electrochemical biosensor. The PDMS/tape composite rapid prototyping technique provides a fast and cost effective fabrication method and can provide easy integration of microfluidic channels with sensors and other components without the need for a cleanroom facility.