Changes in plasma lipids and lipoproteins in humans during a 2-year period of dietary restriction in Biosphere 2.
Changes in plasma lipids and lipoproteins in humans during a 2-year period of dietary restriction in Biosphere 2.
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DOI：
10.1001/archinte.158.8.900
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发表时间：
1998-04
影响因子：
--
通讯作者：
Roy B. Verdery;Roy L Walford
中科院分区：
文献类型：
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作者：
Roy B. Verdery;Roy L Walford
背景 对密封在生物圈 2 号内的 8 个人进行了一项队列研究，以评估饮食限制对人类脂质和脂蛋白水平的影响，以及这些水平与饮食中的能量、脂肪和蛋白质含量以及体重、体重变化和能量消耗的关系。方法从1991年9月26日到1993年9月26日，8名年龄在27岁至67岁之间的健康人，其中4名女性和4名男性，被密封在生物圈2号内，这是有记录以来在“隔离密闭环境”中持续时间最长的一段时间。他们在整个禁闭期间以及离开并恢复随意饮食后两年多的时间里都接受了研究。在生物圈2内两年的大部分时间里，食物供应受到严格限制。高工作量得以维持，食物质量仍然很高，导致能量摄入长期受到限制，但没有出现营养不良。结果 空腹血浆胆固醇、甘油三酯和高密度脂蛋白 (HDL) 胆固醇水平； HDL亚分数分布；膳食能量、脂肪和蛋白质含量摄入；测量身高、体重、体重变化和能量消耗。血浆总胆固醇和甘油三酯水平分别降低 30% 和 45%。 HDL 和低密度脂蛋白水平也有所下降，并且在一些参与者中，HDL2 亚组分的水平有所增加。多变量分析表明，这些变化的主要原因是能量限制。结论能量限制是导致低脂质和脂蛋白水平的主要因素。年轻人和中年人限制能量和充足营养可能会大大降低动脉粥样硬化和随之而来的冠状动脉和脑血管疾病的风险。
BACKGROUND A cohort study was performed of 8 people sealed inside Biosphere 2 to evaluate the effects of dietary restriction in humans on lipid and lipoprotein levels and the relationship of these levels to energy, fat, and protein content of the diet, and body weight, weight change, and energy expenditure. METHODS Eight healthy people aged 27 to 67 years, 4 women and 4 men, were sealed inside Biosphere 2 from September 26, 1991, to September 26, 1993, the longest sustained period in an "isolated confined environment" on record. They were studied throughout confinement and for more than 2 years after their exit and return to an ad libitum diet. Food available was severely restricted during most of the 2-year period inside Biosphere 2. High work output was maintained and food quality remained high, resulting in prolonged restriction of energy intake without malnutrition. RESULTS Fasting plasma cholesterol, triglyceride, and high-density lipoprotein (HDL) cholesterol levels; HDL subfraction distribution; dietary energy, fat, and protein content intake; and height, weight, weight change, and energy expenditure were measured. Total plasma cholesterol and triglyceride levels decreased 30% and 45%, respectively. The HDL and low-density lipoprotein levels also decreased and, in some participants, levels of HDL2 subfractions were increased. Multivariate analysis showed that the major cause of these changes was energy restriction. CONCLUSIONS Energy restriction was the major factor leading to low lipid and lipoprotein levels. Energy restriction with adequate nutrition of young and middle-aged people may substantially reduce risk for atherosclerosis and consequent coronary artery and cerebrovascular disease.