COVID-19 in Amazonas, Brazil, was driven by the persistence of endemic lineages and P.1 emergence
COVID-19 in Amazonas, Brazil, was driven by the persistence of endemic lineages and P.1 emergence
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DOI：
10.1038/s41591-021-01378-7
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发表时间：
2021-05-25
期刊：
影响因子：
82.9
通讯作者：
Bello, Gonzalo
中科院分区：
文献类型：
--
作者：
Naveca, Felipe Gomes;Nascimento, Valdinete;Bello, Gonzalo
北部的亚马逊州是巴西受新冠肺炎疫情影响最严重的地区之一，并在2020年初和年底经历了两次呈指数级增长的疫情。通过对2020年3月至2021年1月从亚马逊不同城市采集的250株SARS冠状病毒(SARS-CoV-2)基因组的基因组流行病学研究，我们发现第一个指数增长阶段主要是由B.1.195世系的传播推动的，在2020年5月至6月期间逐渐被B.1.1.28世系取代。第二波浪潮恰逢关注变种(VOC)P.1的出现，它于2020年11月下旬从当地的B.1.1.28分支进化而来，取代了
The northern state of Amazonas is among the regions in Brazil most heavily affected by the COVID-19 epidemic and has experienced two exponentially growing waves, in early and late 2020. Through a genomic epidemiology study based on 250 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from different Amazonas municipalities sampled between March 2020 and January 2021, we reveal that the first exponential growth phase was driven mostly by the dissemination of lineage B.1.195, which was gradually replaced by lineage B.1.1.28 between May and June 2020. The second wave coincides with the emergence of the variant of concern (VOC) P.1, which evolved from a local B.1.1.28 clade in late November 2020 and replaced the parental lineage in