Changes in mercury concentrations of segmental maternal hair during gestation and their correlations with other biomarkers of fetal exposure to methylmercury in the Japanese population
Changes in mercury concentrations of segmental maternal hair during gestation and their correlations with other biomarkers of fetal exposure to methylmercury in the Japanese population
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DOI：
10.1016/j.envres.2007.10.002
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发表时间：
2008-02-01
影响因子：
8.3
通讯作者：
Satoh, Hiroshi
中科院分区：
文献类型：
--
作者：
Sakamotoa, Mineshi;Kubota, Machi;Satoh, Hiroshi
甲基汞（MeHg）是通过食用鱼类影响胎儿的最危险物质之一。本研究的目的是通过评估分娩时和分娩后3个月的分毛汞浓度来评估甲基汞暴露水平的变化，并研究它们与母体和脐带红细胞（rbc）和新生儿毛发中总汞浓度的相关性，作为胎儿分娩时甲基汞暴露的生物标志物。在分娩时，共收集了40份来自头皮的母亲头发、母亲和脐带红细胞的配对样本，以及21份来自头皮的新生儿头发样本。此外，在分娩后3个月采集了19份母体头皮毛发样本。母亲的头发样本从头皮末端向发梢剪成1厘米的片段。脐带红细胞中汞浓度的几何平均值约为母体红细胞中汞浓度的1.6倍，两者之间存在较强的相关系数（r = 0.91）。妊娠期节段毛中汞浓度的升高或降低在个体间差异很大。在距离头皮1cm的头发段，汞浓度与脐带红细胞的相关系数最强（r = 0.90），随距离头皮的增加而逐渐降低。产后3个月采集的分娩期发中汞浓度与母体红细胞的相关系数在距离头皮5和6 cm的分娩期发中均大于0.9，说明血液中汞进入生长中的头发所需的时间很短。分娩时新生儿头发中汞浓度的几何平均值与分娩时距头皮1 cm的母亲头发中汞浓度的几何平均值相似，两者具有很强的相关性（r = 0.95）。本研究结果表明，分娩时靠近头皮的母亲头发和新生儿头发是胎儿分娩时甲基汞暴露的有用生物标志物。此外，整个妊娠期的母发片段对于获得妊娠期间不同敏感窗口或大剂量甲基汞暴露的重要信息至关重要。(c) 2007爱思唯尔公司版权所有。
Methylmercury (MeHg) is one of the most hazardous substances that affects the fetus through fish consumption. The objective of this study was to evaluate the changes in the level of exposure to MeHg by assessing the mercury (Hg) concentrations of the segmental hair at parturition and 3 months after parturition, and to study their correlations with the total Hg concentrations of maternal and cord red blood cells (RBCs) and neonatal hair as biomarkers of fetal exposure to MeHg at parturition. In total, 40 paired samples of maternal hair from the scalp, maternal and cord RBCs, and 21 samples of neonatal hair from the scalp were collected at parturition. In addition, 19 samples of maternal hair from the scalp were collected at 3 months after parturition. The maternal hair samples were cut into I cm segments from the scalp end toward the tip. The geometric mean of the Hg concentrations in cord RBCs was approximately 1.6 times higher than that in the maternal RBCs, and a strong correlation coefficient (r = 0.91) was found between them. The increase or decrease in the Hg concentrations of the segmental hair during gestation differed largely among individuals. The correlation coefficients between the Hg concentrations of the segmental hair and cord RBCs were the strongest (r = 0.90) in the hair segment I cm from the scalp and decreased gradually with the distance from the scalp. The correlation coefficients between the Hg concentrations of the segmental hair collected at 3 months after parturition and maternal RBCs were over 0.9 in the hair segments 5 and 6 cm from the scalp, suggesting that the time required for the incorporation of Hg from the blood into a growing hair was very short. The geometric mean of Hg concentrations in the neonatal hair at parturition was similar to that in the maternal hair I cm from the scalp at parturition, and they exhibited a strong correlation (r = 0.95). The findings of this study indicate that maternal hair close to the scalp at parturition and neonatal hair are useful biomarkers of fetal exposure to MeHg at parturition. In addition, the segmental maternal hair throughout gestation is essential to obtain important information on MeHg exposure during the different sensitive windows or bolus MeHg exposure during gestation. (c) 2007 Elsevier Inc. All rights reserved.