PPARγ2 C1431T genotype increases metabolic syndrome risk in young men with low cardiorespiratory fitness
PPARγ2 C1431T genotype increases metabolic syndrome risk in young men with low cardiorespiratory fitness
复制标题
DOI：
10.1152/physiolgenomics.00129.2010
复制
发表时间：
2011-02-01
影响因子：
4.6
通讯作者：
Miyachi, Motohiko
中科院分区：
文献类型：
--
作者：
Sanada, Kiyoshi;Iemitsu, Motoyuki;Miyachi, Motohiko
Sanada K, Iemitsu M, Murakami H, Tabata I, Yamamoto K, Gando Y, Suzuki K, Higuchi M, Miyachi M. PPAR γ 2 C1431T基因型增加心血管健康低的年轻男性代谢综合征的风险。中国生物医学工程学报（英文版），2011；首次发表于2010年12月14日；doi: 10.1152 / physiolgenomics.00129.2010。-过氧化物酶体增殖物激活受体γ 2 （PPAR γ 2）基因型与肥胖和代谢综合征（MetS）有关。低水平的心肺健康也是MetS发生的一个重要决定因素。本横断面研究旨在探讨PPAR γ 2基因型和心肺适应性之间的相互作用对MetS风险的影响。健康的日本男性（n = 211）和女性（n = 505）参与了这项研究。所有受试者按性别、体能水平（高、低体能组）、年龄（低龄，年龄< 40岁；中老年，年龄>= 40岁）分为8组。采用Taq-Man探针对PPAR γ 2基因型（Pro12Ala和C1431T）进行实时PCR分析。以年龄为协变量的双向方差分析显示，适应度与PPAR γ 2基因中C1431T的CC基因型相互作用对年轻男性MetS风险产生显著影响，低心肺适应度的CC基因型组的MetS风险显著高于相应的CT + TT基因型组或高适应度组。在确定任何组中老年男性或女性的MetS风险方面，适应度和基因型之间没有显著的相互作用。对于PPAR γ 2基因的Pro12Ala基因型，在适应度和基因型效应上没有显著差异，测量变量之间也没有相互作用。我们得出结论，PPAR γ 2基因中C1431T的CC基因型与低心肺适能可能增加年轻男性（< 40岁）发生MetS的风险，即使对年龄进行调整。
Sanada K, Iemitsu M, Murakami H, Tabata I, Yamamoto K, Gando Y, Suzuki K, Higuchi M, Miyachi M. PPAR gamma 2 C1431T genotype increases metabolic syndrome risk in young men with low cardiorespiratory fitness. Physiol Genomics 43: 103-109, 2011. First published December 14, 2010; doi:10.1152/physiolgenomics.00129.2010.-The peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2) genotypes are related to obesity and the metabolic syndrome (MetS). A low level of cardiorespiratory fitness is also a strong determining factor in the development of MetS. This cross-sectional study was performed to investigate the influence of the interaction between the PPAR gamma 2 genotype and cardiorespiratory fitness on the risk of MetS. Healthy Japanese men (n = 211) and women (n = 505) participated in this study. All subjects were divided into 8 groups according to sex, fitness level (high and low fitness groups), and age (younger, age < 40 yr; middle-aged/older, age >= 40 yr). The PPAR gamma 2 genotypes (Pro12Ala and C1431T) were analyzed by real-time PCR with Taq-Man probes. Two-way ANCOVA with adjustment for age as a covariate indicated that fitness and the CC genotype of C1431T in the PPAR gamma 2 gene interacted to produce a significant effect on MetS risk in younger men and that the risk of MetS in the CC genotype group with low cardiorespiratory fitness was significantly higher than that in the corresponding CT + TT genotypes or in the high fitness groups. There was no significant interaction between fitness and genotype in determining MetS risk in middle-aged/older men or in women in any group. With regard to the Pro12Ala genotype of the PPAR gamma 2 gene, there were no significant differences in fitness or genotype effects nor were there any interactions between measurement variables. We concluded that the CC genotype of C1431T in the PPAR gamma 2 gene together with low cardiorespiratory fitness may increase the risk of MetS in younger men (age < 40 yr), even with adjustment for age.