Green tea consumption and prostate cancer risk in Japanese men: A prospective study
Green tea consumption and prostate cancer risk in Japanese men: A prospective study
复制标题
DOI：
10.1093/aje/kwm249
复制
发表时间：
2008-01-01
影响因子：
5
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Kurahashi, Norie;Sasazuki, Shizuka;Tsugane, Shoichiro
亚洲人前列腺癌的发病率比西方人低得多。考虑到饮食习惯等环境因素可能在亚洲人群中前列腺癌的病因和绿色茶的高消费中起主要作用，这种低发病率可能部分归因于绿色茶的影响。JPHC研究（基于日本公共卫生中心的前瞻性研究）于1990年针对队列I建立，1993年针对队列II建立。受试者为49,920名年龄在40-69岁之间的男性，他们完成了一份问卷调查，其中包括基线时的绿色茶消费习惯，并随访至2004年底。在此期间，404名男性新诊断为前列腺癌，其中114名为晚期病例，271名为局部病例，19名为未确定的阶段。绿色茶与局限性前列腺癌无关。然而，消费与晚期前列腺癌风险的剂量依赖性降低相关。多变量相对风险为0.52（95%置信区间：0.28，0.96），男性饮用5杯或更多杯/天相比，少于1杯/天（p（趋势）= 0.01）。绿色茶可能与晚期前列腺癌风险降低有关。
The incidence of prostate cancer is much lower in Asian than Western populations. Given that environmental factors such as dietary habits may play a major role in the causation of prostate cancer and the high consumption of green tea in Asian populations, this low incidence may be partly due to the effects of green tea. The JPHC Study (Japan Public Health Center-based Prospective Study) was established in 1990 for cohort I and in 1993 for cohort II. The subjects were 49,920 men aged 40-69 years who completed a questionnaire that included their green tea consumption habit at baseline and were followed until the end of 2004. During this time, 404 men were newly diagnosed with prostate cancer, of whom 114 had advanced cases, 271 were localized, and 19 were of an undetermined stage. Green tea was not associated with localized prostate cancer. However, consumption was associated with a dose-dependent decrease in the risk of advanced prostate cancer. The multivariate relative risk was 0.52 (95% confidence interval: 0.28, 0.96) for men drinking 5 or more cups/day compared with less than 1 cup/day (p(trend) = 0.01). Green tea may be associated with a decreased risk of advanced prostate cancer.