Catalytic asymmetric Hiyama cross-couplings of racemic α-bromo esters
Catalytic asymmetric Hiyama cross-couplings of racemic α-bromo esters
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DOI：
10.1021/ja8009428
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发表时间：
2008-03-19
影响因子：
15
通讯作者：
Fu, Gregory C.
中科院分区：
文献类型：
--
作者：
Dai, Xing;Strotman, Neil A.;Fu, Gregory C.
首次实现了α-卤代碳化合物与芳基金属试剂的催化不对称交叉偶联反应，从而合成了具有良好对映体丰度的合成有用的α-芳基羧酸衍生物。该方法也可用于对映选择性的烯烃基化反应。
The first catalytic asymmetric cross-coupling of alpha-halo carbono compounds with aryl metal reagents has been developed, thereby generating synthetically useful alpha-aryl carboxylic acid derivatives in good enantiomeric excess. The method can also be applied to enantioselective alkenylation reactions.