Prevalence of oral and oropharyngeal human papillomavirus in a sample of South African men: A pilot study
Prevalence of oral and oropharyngeal human papillomavirus in a sample of South African men: A pilot study
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DOI：
10.7196/samj.7542
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发表时间：
2014-05-01
期刊：
影响因子：
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通讯作者：
Boy, S C
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文献类型：
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作者：
Davidson, C L;Richter, K L;Boy, S C
背景众所周知，人乳头瘤病毒（HPV）感染与头颈癌（HNC）有关。HPV相关的HNC与性行为有关，特别是与一生中口交伴侣的数量有关，但南非男性口腔和口咽HPV的流行病学尚未研究。确定南非（SA）比勒陀利亚选定的男性人群中口腔和口咽部HPV株的患病率及其相关因素。工厂招聘了男性工人。使用线性阵列HPV基因分型测试（Roche Molecular Systems）测试口腔冲洗液和漱口液样品的37种HPV类型。调查问卷用于获取有关年龄、医疗条件、药物和酒精使用以及性行为的信息。HIV检测是可选的。17 - 64岁男性（N=125）中HPV感染率为5.6%。在两名男性中发现了高危型HPV（hrHPV）16和68型。在大多数受访者中，口交似乎是一种不常见的做法，但两名患有hrHPV的受访者确实进行了口交。HPV感染与性伴侣数量增加之间存在统计学显著相关性（p=0.027），但与物质使用、HIV状态或临床粘膜病理学之间无相关性。口腔和口咽部HPV的患病率低于其他国家的报告。口腔HPV和有多个性伴侣之间的关联被发现。一个更大的全国性研究将提供一个更有代表性的观点，口腔和口咽HPV感染的负担在SA。
Background. Human papillomavirus (HPV) infection is well known to be associated with head and neck cancers (HNCs). HPV-associated HNCs are related to sexual behaviour, particularly the lifetime number of oral sex partners, but the epidemiology of oral and oropharyngeal HPV in South African men has not yet been studied.Objectives. To determine the oral and oropharyngeal HPV strain prevalence and associated factors in a selected male population in Pretoria, South Africa (SA).Methods. Male factory workers were recruited. Oral rinse and gargle samples were tested for 37 HPV types using the Linear Array HPV Genotyping Test (Roche Molecular Systems). A questionnaire was used to obtain information regarding age, medical conditions, substance and alcohol use and sexual behaviour. HIV testing was optional.Results. The HPV prevalence was 5.6% among men (N=125) aged 17 - 64 years. High-risk HPV (hrHPV) types 16 and 68 were found in two men. Oral sex seemed to be an uncommon practice in the majority of respondents, but the two respondents with hrHPV did practise oral sex. There was a statistically significant association between HPV infection and an increased number of sexual partners (p=0.027), but not between HPV and substance use, HIV status or clinical mucosal pathology.Conclusion. The prevalence of oral and oropharyngeal HPV was lower than reported in other countries. An association between oral HPV and having multiple sexual partners was found. A larger nationwide study would give a more representative view of the burden of oral and oropharyngeal HPV infection in SA.