Angiotensin-Sodium Interaction in Blood Pressure Maintenance of Renal Hypertensive and Normotensive Rats
Angiotensin-Sodium Interaction in Blood Pressure Maintenance of Renal Hypertensive and Normotensive Rats
复制标题
血管紧张素-钠相互作用在肾高血压和正常血压大鼠血压维持中的作用
作者：
H. Gavras;H. Brunner;E. Vaughan;J. Laragh
在大鼠中使用血管紧张素II的特异性抑制剂来研究血管紧张素是否参与单肾Goldblatt高血压的血压维持，其中血浆肾素水平通常不增加。这种抑制剂使血压显著福尔斯下降，通常只有当高血压动物的钠耗尽时才能降到正常水平，而在钠补充后则不能。血压正常的钠缺乏大鼠的血压也出现了小得多但仍显着的福尔斯下降，但在饱足大鼠中则没有。我们的结论是，血管紧张素维持血压的重要性在很大程度上取决于其与可用钠或液体体积的关系，因为在维持高血压或血压正常状态的肾素组分只能通过钠剥夺来暴露。因此，容量扩张本身或其他升压因子可能参与维持这些钠充足的血压正常或高血压动物的血压。
A specific inhibitor of angiotensin II was used in rats to investigate whether angiotensin is involved in the maintenance of blood pressure in one-kidney Goldblatt hypertension, in which plasma renin levels are not usually increased. The inhibitor produced marked falls in blood pressure, often down to normal levels in the hypertensive animals only when they were depleted in sodium and not after sodium repletion. Much lesser but still significant falls in blood pressure were also produced in normotensive sodium-depleted rats but not in repleted rats. We conclude that the importance of angiotensin for maintaining blood pressure is largely determined by its relation to available sodium or fluid volume, since the renin component in maintenance of either the hypertensive or the normotensive state could be exposed only by sodium deprivation. Therefore, volume expansion per se or other pressor factors may be involved in maintaining blood pressure of these sodium-replete normotensive or hypertensive animals.