Circulating immune complexes, the concentration of serum IgA and the distribution of HLA antigens in IgA nephropathy.
Circulating immune complexes, the concentration of serum IgA and the distribution of HLA antigens in IgA nephropathy.
复制标题
IgA 肾病中循环免疫复合物、血清 IgA 浓度和 HLA 抗原的分布。
作者：
J. Mustonen;A. Pasternack;H. Helin;A. Rilva;K. Penttinen;O. Wager;A. Harmoinen
本文报告40例伊加肾病患者。伊加肾病是最常见的（24%）类型的肾小球肾炎，在我们的肾活检材料。通过五种方法测量循环免疫复合物，在9-69%的患者中得到阳性结果。加热血清血小板聚集试验（PAT 2）是迄今为止最常见的阳性。采用放射免疫扩散法和激光散射比浊法测定血清伊加浓度。两次测试的结果相似。58%的患者血清伊加升高。与对照组相比，HLA抗原与伊加肾病之间无统计学显著相关性。
A series of 40 IgA nephropathy patients is presented. IgA nephropathy was the most common (24%) type of glomerulonephritis in our renal biopsy material. Circulating immune complexes were measured by five methods that gave a positive result in 9-69% of the patients. The platelet aggregation test with heated serum (PAT2) was by far the most commonly positive. The serum concentrations of IgA were measured by two methods, radial immunodiffusion and laser nephelometry. Both tests gave similar results. 58% of the patients had elevated serum IgA. There was no statistically significant association between HLA antigens and IgA nephropathy as compared with the control material.