Evaluating the menopausal transition with the STRAW + 10 in a Brazilian cohort of women with HIV, 2015-2016.
Evaluating the menopausal transition with the STRAW + 10 in a Brazilian cohort of women with HIV, 2015-2016.
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使用 STRAW 10 评估 2015-2016 年巴西艾滋病毒感染女性队列的绝经过渡情况。
DOI：
10.1080/13697137.2021.1889501
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Grinsztejn,B
中科院分区：
文献类型：
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作者：
Jalil,EM;Domingues,RM;Derrico,M;Dias,MB;Andrade,ACV;Rocha,VSO;Nazer,S;Feitosa,M;Cardoso,SW;Veloso,VG;Friedman,RK;Grinsztejn,B
背景更年期转变是一个生理过程，包括影响妇女健康和生活质量的荷尔蒙和身体变化。这一时期的特征可能是生殖老龄化研讨会(STRAN+10)标准使用月经模式的阶段。在HIV感染中使用稻草+10还不确定。我们的目标是用稻草+10标准、荷尔蒙测量和更年期症状来描述感染艾滋病毒(WWH)妇女的绝经转变。符合条件的女性包括年龄在30 或以上，没有临床或手术绝经，没有激素避孕，替代治疗和卵巢疾病的女性。我们进行了面对面的访谈，并采集了卵泡刺激素(FSH)和雌二醇的血样。结果我们招募了328名WWH(28.3%的队列女性)。每个稻草+10阶段的年龄、激素水平和报告的症状的分布与更年期过渡的预期分布一致。−2期(月经延迟7 + 天)至+2期(闭经8 + 年)，年龄、卵泡刺激素显著增加，雌二醇显著下降。结论用稻草+10作为绝经过渡期的指标，具有良好的临床和免疫学控制。
BackgroundMenopausal transition is a physiological process encompassing hormonal and body changes that impact women’s health and life quality. This period may be characterized by the Stages of Reproductive Aging Workshop (STRAW + 10) criteria using menstrual patterns. Use of the STRAW + 10 is uncertain in HIV infection. We aimed to characterize menopausal transition in women with HIV (WWH) using the STRAW + 10 criteria, hormonal measures and menopause symptoms.MethodsWe performed a cross-sectional study, nested to the HIV-Infected Women’s Cohort, in Rio de Janeiro, Brazil. Eligible women included those aged 30 years or older, without clinical or surgical menopause, hormonal contraception, replacement therapy and ovarian disorders. We conducted face-to-face interviews and collected blood samples for follicle stimulating hormone (FSH) and estradiol measures.ResultsWe enrolled 328 WWH (28.3% of women in the cohort). The distribution of age, hormonal levels and reported symptoms per each STRAW + 10 stage was consistent with the expected distribution in the menopausal transition. Age and FSH significantly increased and estradiol decreased from stage −2 (7 + days of menstrual delay) to stage +2 (8 + years of amenorrhea).ConclusionsThe present results support use of the STRAW + 10 to characterize the menopausal transition of WWH with good clinical and immunological control.