Rab GTPases in cilium formation and function.
Rab GTPases in cilium formation and function.
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DOI：
10.1080/21541248.2017.1353847
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发表时间：
2018-03-04
期刊：
影响因子：
--
通讯作者：
Kuhns S
中科院分区：
文献类型：
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作者：
Blacque OE;Scheidel N;Kuhns S
纤毛是基于微管的细胞器，从真核细胞表面的基体延伸出来。纤毛调节细胞和液体运动、感觉和发育信号，纤毛缺陷导致影响许多组织和器官形成和功能的人类疾病（纤毛病）。在过去的十年中，各种Rab和Rab样膜运输蛋白已被证明可以调节与纤毛相关的过程，如基体成熟、纤毛轴突延伸、鞭毛内运输和纤毛信号传导。在这篇综述中，我们提供了Rab蛋白纤毛关联的全面概述，借鉴了多个模型系统的发现，包括哺乳动物细胞培养、小鼠、斑马鱼、秀丽隐杆线虫、锥虫和绿藻。我们还讨论了与纤毛拉布级联和功能冗余相关的几个新兴机制主题。
Cilia are microtubule-based organelles extending from a basal body at the surface of eukaryotic cells. Cilia regulate cell and fluid motility, sensation and developmental signaling, and ciliary defects cause human diseases (ciliopathies) affecting the formation and function of many tissues and organs. Over the past decade, various Rab and Rab-like membrane trafficking proteins have been shown to regulate cilia-related processes such as basal body maturation, ciliary axoneme extension, intraflagellar transport and ciliary signaling. In this review, we provide a comprehensive overview of Rab protein ciliary associations, drawing on findings from multiple model systems, including mammalian cell culture, mice, zebrafish, C. elegans, trypanosomes, and green algae. We also discuss several emerging mechanistic themes related to ciliary Rab cascades and functional redundancy.