Early-onset colorectal cancer with stable microsatellite DNA and near-diploid chromosomes
Early-onset colorectal cancer with stable microsatellite DNA and near-diploid chromosomes
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DOI：
10.1038/sj.onc.1204653
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发表时间：
2001-08-09
期刊：
影响因子：
8
通讯作者：
Yuen, ST
中科院分区：
文献类型：
--
作者：
Chan, TL;Curtis, LC;Yuen, ST
结直肠癌被描述为选择性影响微卫星序列 (MIN) 或染色体数目和结构 (CIN) 的遗传不稳定性。还存在一个具有明显稳定、近二倍体染色体和稳定微卫星（MACS）的亚群。这些区别很重要，部分是因为它们在强调不同的致癌途径方面具有价值，部分是因为它们与预后直接相关。早发癌症的研究常常被证明是鉴定癌症易感基因的性质和功能的丰富资源。在一项针对具有稳定微卫星 DNA 的结直肠癌的研究中，我们描述了 22 种早发肿瘤（平均年龄 = 33 岁），与 16 种晚发肿瘤（平均年龄 = 68 岁）进行了比较。两组均含有具有 MACS 表型的癌，其特征是通过流式细胞术定义的接近二倍体 DNA 含量，以及通过比较基因组杂交 (CGH) 确定的最小染色体臂缺失或扩增（每个基因组 6 个或更少的事件）。最小染色体不平衡与二倍体 DNA 含量密切相关 (P
Colorectal cancer has been described in terms of genetic instability selectively affecting either microsatellite sequences (MIN) or chromosome number and structure (CIN). A subgroup with apparently stable, near-diploid chromosomes and stable microsatellites (MACS) also exists. These distinctions are important, partly because of their value in highlighting different pathways of carcinogenesis, and partly because of their direct relevance to prognosis. Study of early-onset cancer has often proved a fruitful resource for the identification of the nature and function of cancer susceptibility genes. In a study of colorectal cancer with stable microsatellite DNA, we describe 22 early-onset tumours (mean age = 33), compared with 16 late-onset tumours (mean age = 68). Both groups contained carcinomas with the MACS phenotype, characterized by near diploid DNA content, as defined by flow cytometry, and minimal chromosome arm deletion or amplification (six or less events per genome), determined by comparative genomic hybridization (CGH). Minimal chromosome imbalance correlated strongly with diploid DNA content (P