Lethal outcome of uterine infection in pregnant but not in nonpregnant rats and increased death rate with inhibition of nitric oxide.
Lethal outcome of uterine infection in pregnant but not in nonpregnant rats and increased death rate with inhibition of nitric oxide.
复制标题
妊娠大鼠子宫感染的致命结果而非非妊娠大鼠的致命结果，并且抑制一氧化氮会增加死亡率。
DOI：
10.1111/j.1600-0897.1997.tb00521.x
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
Yallampalli,C
中科院分区：
文献类型：
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作者：
Nowicki,B;Fang,L;Singhal,J;Nowicki,S;Yallampalli,C
问题：有限的信息是可用的潜在差异，在敏感性泌尿生殖道感染之间的怀孕和nonpregnant hosts.Method研究：在这项研究中，我们evaluatedEscherichia coli感染并发症在怀孕和nonpregnant大鼠和一氧化氮（NO）抑制剂的效果，NG-nitro-l-arginine methyl ester（L-NAME），对一个实验性子宫感染的结果。结果：在感染的怀孕动物，31%被发现死亡在24 - 48 hr.The死亡率增加了2倍（66%）与L-NAME治疗。在有或无l-NAME给药的非妊娠动物中未发生死亡。妊娠动物的子宫感染率比非妊娠动物高约10倍。结论：妊娠期感染性并发症可能与妊娠期对病原微生物的敏感性和宿主NO状态有关。
PROBLEM:Limited information is available on potential differences in sensitivity to urogenital infections between pregnant and nonpregnant hosts.METHOD OF STUDY:In this study, we evaluatedEscherichia coliinfectious complications in pregnant and nonpregnant rats and the effect of nitric oxide (NO) inhibitor, NG‐nitro‐l‐arginine methyl ester (l‐NAME), on the outcome of an experimental uterine infection.RESULTS:Of the infected pregnant animals, 31% were found dead in 24–48 hr. The death rate was increased 2‐fold (66%) withl‐NAME treatment. No deaths occurred in nonpregnant animals with or withoutl‐NAME treatment. The rate of uterine infection in pregnant animals was about 10‐fold higher than in nonpregnant animals.CONCLUSION:We propose that infectious complications of pregnancy may be related to gestation‐dependent sensitivity to the pathogenic microorganism and the host NO status.