Effect of Different Morphology of Titanium Surface on the Bone Healing in Defects Filled Only with Blood Clot: A New Animal Study Design
Effect of Different Morphology of Titanium Surface on the Bone Healing in Defects Filled Only with Blood Clot: A New Animal Study Design
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DOI：
10.1155/2018/4265474
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发表时间：
2018-01-01
影响因子：
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通讯作者：
De Aza, Piedad N.
中科院分区：
文献类型：
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作者：
Alexandre Gehrke, Sergio;Dedavid, Berenice Anina;De Aza, Piedad N.
背景。本组织学动物研究的目的是使用兔胫骨模型分析钛表面的粗糙度是否会影响和/或刺激充满血液的缺损处的骨生长。材料和方法。将四十套（种植体和基台）、牙种植体（直径 3.5 毫米，长度 7 毫米）加上愈合基台（直径 2.5 毫米）插入 10 只兔子的胫骨中。另外，准备了20个钛圆盘。基台和椎间盘采用 4 种不同的方法进行处理，并分为 4 组：（A 组）机加工基台（光滑）； (B组)双酸蚀处理； (C组)用氧化铝颗粒喷砂加酸调节进行喷砂处理； （D组）用氧化钛颗粒彻底喷砂加酸调节的处理。这些圆盘用于通过轮廓仪和扫描电子显微镜来表征表面。结果。 8周后，根据距植入物基部的骨高度和骨细胞的存在，对样品组周围的新骨形成进行定性和定量分析。 C组（1.50±0.20mm）和D组（1.62±0.18mm）基台骨生长值高于A组（0.94±0.30mm）和B组（1.19±0.23mm），组间差异显着（P < 0.05）。此外，在进行与机加工相关的表面处理的组中，骨细胞的存在率较高（P < 0.05）。结论。在本研究的局限性内，可以观察到钛表面的粗糙度与骨形成的刺激之间存在直接关系，因为 SLA 表面上存在大量骨细胞证明了这一事实。此外，骨组织高度形成的增加表明，用于表面处理的物理方法和化学方法之间存在重要差异。
Background. The objective of the present histologic animal study was to analyze whether roughness of the titanium surface can influence and/or stimulate the bone growth in defects filled with the blood using a rabbit tibia model. Materials and Methods. Forty sets (implant and abutment), dental implant (3.5 mm in diameter and 7 mm in length) plus healing abutment (2.5 mm in diameter), were inserted in the tibiae of 10 rabbits. Moreover, twenty titanium discs were prepared. The abutment and discs were treated by 4 different methods and divided into 4 groups: (group A) machined abutments (smooth); (group B) double acid etching treatment; (group C) treatment with blasting with particles of alwninum oxide blasted plus acid conditioning; (group D) treatment with thorough blasting with particles of titanium oxide plus acid conditioning. The discs were used to characterize the surfaces by a profilometer and scanning electronic microscopy. Results. After 8 weeks, the new bone formation around the sets of the samples was analyzed qualitatively and quantitatively in relation to bone height from the base of the implant and presence of osteocytes. Group C (1.50 +/- 0.20 mm) and group D (1.62 +/- 0.18 mm) showed bone growth on the abutment with higher values compared to group A (0.94 +/- 0.30 mm) and group B (1.19 +/- 0.23 mm), with significant difference between the groups (P < 0.05). In addition, osteocyte presence was higher in groups with surface treatment related to machined (P < 0.05). Conclusions. Within the limitations of the present study, it was possible to observe that there is a direct relationship between the roughness present on the titanium surface and the stimulus for bone formation, since the presence of larger amounts of osteocytes on SLA surfaces evidenced this fact. Furthermore, the increased formation of bone tissue in height demonstrates that there is an important difference between the physical and chemical methods used for surface treatment.