TUBULAR SECRETION OF CREATINE, TRIMETHYLAMINE OXIDE, AND OTHER ORGANIC BASES BY THE AGLOMERULAR KIDNEY OF LOPHIUS-AMERICANUS
TUBULAR SECRETION OF CREATINE, TRIMETHYLAMINE OXIDE, AND OTHER ORGANIC BASES BY THE AGLOMERULAR KIDNEY OF LOPHIUS-AMERICANUS
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DOI：
10.1085/jgp.42.2.319
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发表时间：
1958-01-01
影响因子：
3.8
通讯作者：
RENNICK, BR
中科院分区：
文献类型：
--
作者：
FORSTER, RP;BERGLUND, F;RENNICK, BR
肌酸和三甲胺氧化物(TMAO)是正常刘柔斯尿的主要含氮成分，这两种有机碱的特点是尿液/血浆浓度比高。涉及各种有机碱基的竞争研究表明，肌酸和TMAO是通过不同的运输机制独立排泄的。TMAO的排泄被四乙基铵离子(TEA)和863号菁染料[Long dash]化合物竞争性地抑制，这些化合物以前被证明是通过一种在脊椎动物中普遍存在的有机碱分泌机制主动转移的。TEA不竞争性地抑制TMAO在Sgualus体内的主动小管重吸收，剂量显著抑制其在Lophius体内的小管排泄。抑制犬体内肌酸重吸收的甘氨酸，不会竞争性地干扰其在Lophius体内的分泌。
Creatine and trimethylamine oxide (TMAO) are the chief nitrogenous constituents of normal Lophius urine, and both of these organic bases characteristically have high urine/plasma concentration ratios. Competition studies involving various organic bases indicate that creatine and TMAO are excreted independently by separate transport mechanisms. TMAO excretion is inhibited competitively by tetraethylammonium ion (TEA) and by cyanine dye No. 863[long dash]compounds previously shown to be transferred actively by an organic base-secreting mechanism of general occurrence among vertebrates. TEA does not inhibit competitively the active tubular reabsorption of TMAO in Sgualus with doses which markedly depress its tubular excretion in Lophius. Glycine, which inhibits creatine reabsorption in the dog, does not interfere competitively with its secretion in Lophius.