Association study of the dopamine and serotonin transporter genetic polymorphisms and methamphetamine abuse in Chinese males
Association study of the dopamine and serotonin transporter genetic polymorphisms and methamphetamine abuse in Chinese males
复制标题
DOI：
10.1007/s00702-002-0790-8
复制
发表时间：
2003-04-01
影响因子：
3.3
通讯作者：
Tsai, SJ
中科院分区：
文献类型：
--
作者：
Hong, CJ;Cheng, CY;Tsai, SJ
多巴胺转运体（DAT）和5-羟色胺转运体（5-HTT）在甲基苯丙胺（METH）依赖中起重要作用，因为它们是METH作用的靶点。在这项研究中，DAT和5-HTT多态性和甲基苯丙胺依赖之间的关联进行了调查，为中国男性样本人群。研究的多态性包括DAT 3 '-可变数目串联重复序列多态性、5-HTT基因启动子多态性和5-HTT可变数目串联重复序列多态性。当比较METH依赖和对照病例的DAT和5-HTT多态性时，基因型或等位基因频率没有显着差异。本研究的结果表明，这些多态性并没有发挥主要作用，在中国男性人群的甲基苯丙胺依赖。
The dopamine transporter (DAT) and the serotonin transporter (5-HTT) play important roles in methamphetamine (METH) dependence because they are the target of METH action. For this study, the association between the DAT and 5-HTT polymorphisms and METH dependence were investigated for a Chinese-male sample population. The investigated polymorphisms included those of the DAT 3'-variable number tandem repeat, the 5-HTT gene promoter and a 5-HTT variable number tandem repeat polymorphisms. No significant difference was demonstrated for genotype or allele frequency, when comparing METH dependent and control cases for the DAT and the 5-HTT polymorphisms. The findings of this study suggest that these polymorphisms do not play major roles in METH dependence in the Chinese-male population.