Photoreceptors in diabetic retinopathy.
Photoreceptors in diabetic retinopathy.
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DOI：
10.1111/jdi.12312
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发表时间：
2015-07
影响因子：
3.2
通讯作者：
Berkowitz BA
中科院分区：
文献类型：
--
作者：
Kern TS;Berkowitz BA
尽管光感受器负责视网膜的大部分质量和代谢活动，但它们在糖尿病视网膜病变发病机制中的作用在很大程度上被忽视了。最近的研究表明，光感受器可能在糖尿病引起的视网膜毛细血管变性中发挥关键作用，因此不能再被忽视。本综述总结了糖尿病引起的光感受器结构和功能的改变，并为进一步研究光感受器在视网膜病变发病机制中的作用提供了理论基础。
Although photoreceptors account for most of the mass and metabolic activity of the retina, their role in the pathogenesis of diabetic retinopathy has been largely overlooked. Recent studies suggest that photoreceptors might play a critical role in the diabetes-induced degeneration of retinal capillaries, and thus can no longer be ignored. The present review summarizes diabetes-induced alterations in photoreceptor structure and function, and provides a rationale for further study of a role of photoreceptors in the pathogenesis of the retinopathy.