The CTC-chip: an exciting new tool to detect circulating tumor cells in lung cancer patients.
The CTC-chip: an exciting new tool to detect circulating tumor cells in lung cancer patients.
复制标题
DOI：
10.1097/jto.0b013e3181989565
复制
发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Lynch TJ
中科院分区：
文献类型：
--
作者：
Sequist LV;Nagrath S;Toner M;Haber DA;Lynch TJ
循环肿瘤细胞（CTCs）是一种罕见的细胞，来源于恶性肿瘤，并在外周血中自由循环。捕获和研究CTCs的能力是一个新兴领域，对癌症的早期检测、诊断、预后判断和监测以及对转移过程的基础生物学理解都具有重要意义。在此，我们回顾了一种用于分离这些细胞的新型微流控平台——CTC芯片的开发和初步临床研究，并讨论了它在肺癌研究中的潜在用途。
Circulating tumor cells (CTCs) are rare cells that originate from a malignancy and circulate freely in the peripheral blood. The ability to capture and study CTCs is an emerging field with implications for early detection, diagnosis, determining prognosis and monitoring of cancer, as well as for understanding the fundamental biology of the process of metastasis. Here, we review the development and initial clinical studies with a novel microfluidic platform for isolating these cells, the CTC-chip, and discuss its potential uses in the study of lung cancer.