Combined linkage and association sib-pair analysis for quantitative traits
Combined linkage and association sib-pair analysis for quantitative traits
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DOI：
10.1086/302193
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发表时间：
1999-01-01
影响因子：
9.8
通讯作者：
Hewitt, JK
中科院分区：
文献类型：
--
作者：
Fulker, DW;Cherny, SS;Hewitt, JK
An extension to current maximum-likelihood variance-components procedures for mapping quantitative-trait loci in sib pairs that allows a simultaneous test of allelic association is proposed. The method involves modeling of the allelic means for a test of association, with simultaneous modeling of the sib-pair covariance structure for a test of linkage. By partitioning of the mean effect of a locus into between- and within-sibship components, the method controls for spurious associations due to population stratification and admixture. The power and efficacy of the method are illustrated through simulation of various models of both real and spurious association.
