NEURAL MECHANISMS INVOLVED IN ITCH, ITCHY SKIN, AND TICKLE SENSATIONS
NEURAL MECHANISMS INVOLVED IN ITCH, ITCHY SKIN, AND TICKLE SENSATIONS
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DOI：
10.1172/jci102414
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发表时间：
1951-01-01
影响因子：
15.9
通讯作者：
WOLFF, HG
中科院分区：
文献类型：
--
作者：
GRAHAM, DT;GOODELL, H;WOLFF, HG
瘙痒的感觉有两个主观上可以区分的成分，“刺痛”和“灼热”。这些与皮肤疼痛的两种性质相对应，并分别由参与皮肤疼痛传递的两种类型的神经纤维介导。皮肤发痒和“皮肤发痒”在本质上与发痒没有区别，它们是由相同的神经结构调节的。当出现瘙痒时，该部位的痛阈值低于不瘙痒的间歇期。发痒、皮肤发痒和发痒都可以通过在相邻皮肤上针刺来消除。在瘙痒的情况下，如果皮肤被刺到包含瘙痒部位的皮肤刀的任何地方，就会发生这种破坏。发痒、皮肤发痒和发痒不会发生在继发性痛觉过敏的区域。当疼痛感受器受到微弱刺激时，就会出现瘙痒。据推测，这种感觉是由于中枢神经系统(可能是脊髓)中存在在黑质间神经元回路中传播的脉冲所致。
The sensation of itch has 2 subjectively distinguishable components, "pricking" and "burning." These correspond to the 2 qualities of cutaneous pain, and are mediated respectively by the 2 types of nerve fibers involved in the transmission of pain from the skin. Cutaneous tickle and "itchy skin" do not differ qualitatively from itch, and are mediated by the same neural structures. When itching is present, the pain threshold at the site is lower than during itch-free intervals. Tickle, "itchy skin," and itch are abolished by pin pricks in adjacent skin. In the case of itch, this abolition occurs if the skin is pricked anywhere in the dermatome which contains the site of itching. Tickle, "itchy skin," and itch do not occur in areas of secondary hyperalgesia. Itch occurs when pain receptors are weakly stimulated. It is suggested that the sensation results from the presence in the central nervous system, probably in the spinal cord, of impulses traveling in circuits of internuncial neurons.