Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms.
Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms.
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DOI：
10.1021/jf800046n
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发表时间：
2008-04
影响因子：
6.1
通讯作者：
A. S. Wilkinson;G. Monteith;P. Shaw;Chun-Nam Lin;M. Gidley;S. Roberts-Thomson
中科院分区：
文献类型：
--
作者：
A. S. Wilkinson;G. Monteith;P. Shaw;Chun-Nam Lin;M. Gidley;S. Roberts-Thomson
芒果是具有潜在健康促进活性的生物活性化合物的来源。本研究评估芒果成分槲皮素和芒果苷以及芒果苷的糖苷配基衍生物去甲甲状腺素调节过氧化物酶体增殖物激活受体亚型（PPARs）反式激活的能力。PPARs是在许多人类疾病中重要的转录因子。通过使用基因报告分析，表明槲皮素抑制所有三种PPARs亚型的活化（PPARgamma IC（50）= 56.3 μ M; PPARalpha IC（50）= 59.6 μ M; PPARbeta IC（50）= 76.9 μ M），去甲甲状腺素也是如此（PPARgamma IC（50）= 153.5 μ M; PPARalpha IC（50）= 92.8 μ M; PPARbeta IC（50）= 102.4 μ M），而芒果苷不抑制任何同种型的反式激活。这些发现表明，芒果成分和代谢物可能会改变转录，并可能通过这种或类似机制对健康产生积极影响。
Mangos are a source of bioactive compounds with potential health-promoting activity. This study evaluated the abilities of the mango components quercetin and mangiferin and the aglycone derivative of mangiferin, norathyriol, to modulate the transactivation of peroxisome proliferator-activated receptor isoforms (PPARs). PPARs are transcription factors important in many human diseases. Through the use of a gene reporter assay it was shown that quercetin inhibited the activation of all three isoforms of PPARs (PPARgamma IC(50) = 56.3 microM; PPARalpha IC(50) = 59.6 microM; PPARbeta IC(50) = 76.9 microM) as did norathyriol (PPARgamma IC(50) = 153.5 microM; PPARalpha IC(50) = 92.8 microM; PPARbeta IC(50) = 102.4 microM), whereas mangiferin did not inhibit the transactivation of any isoform. These findings suggest that mango components and metabolites may alter transcription and could contribute to positive health benefits via this or similar mechanisms.