Association of mitochondrial haplogroup D and risk of esophageal cancer in Taihang Mountain and Chaoshan areas in China
Association of mitochondrial haplogroup D and risk of esophageal cancer in Taihang Mountain and Chaoshan areas in China
复制标题
太行山和潮汕地区线粒体单倍群D与食管癌风险的关系
DOI：
10.1016/j.mito.2010.06.005
复制
发表时间：
2011-01-01
期刊：
影响因子：
4.4
通讯作者：
Tian, Dong-Ping
中科院分区：
文献类型：
--
作者：
Li, Xiao-Yun;Guo, Yu-Bai;Tian, Dong-Ping
我国中北部的太行山区和东南部沿岸的潮汕地区均为食管癌高发区。我们的前期研究证实了潮汕两地人群可能具有相似的母系遗传背景，并发现线粒体DNA单倍群D，特别是D4a和D5a亚群可能是潮汕地区EC的遗传背景标记。在此，为了进一步确定D4a、D5a和D是否可能是两个高风险地区EC的易感性标志物，我们进行了一项较大样本的病例对照研究，并分析了这三个单倍型群在两个地区受试者（对照[n = 898]和患者[n = 768]）中的分布。D4a单倍型与太行山区人群尤其是女性食管癌发病风险显著相关。05单倍群与太行山区普通人群水平和个体水平的食管癌相关
Both the Taihang Mountain area in north-central China and Chaoshan area in the southeastern littoral of China are areas with high risk of esophageal cancer (EC). Our previous study confirmed that populations from the two areas might share similar matrilineal backgrounds and found that mitochondrial DNA (mtDNA) haplogroup D, especially subhaplogroups D4a and D5a, might be genetic background markers of EC in Chaoshan area. Here, to further determine whether D4a, D5a, and D might be susceptibility markers for EC in the two high-risk areas, we performed a case-control study with larger samples and analyzed the distributions of these three haplogroups in subjects (controls [n = 898] and patients [n = 768]) from the two areas. D4a haplogroup was significantly associated with increased risk of EC in Taihang Mountain subjects, especially women. 05 haplogroup was associated with EC at the general population level in the Taihang Mountain area and in subjects