Folate, cancer risk, and the Greek god, Proteus: a tale of two chameleons.
Folate, cancer risk, and the Greek god, Proteus: a tale of two chameleons.
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DOI：
10.1111/j.1753-4887.2009.00190.x
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发表时间：
2009-04
影响因子：
6.1
通讯作者：
Mason JB
中科院分区：
文献类型：
--
作者：
Mason JB
有证据表明，大量摄入富含叶酸的食物可以预防结直肠癌的发展，也许还可以预防其他一些常见的癌症。然而，这个问题是一个复杂的问题，因为动物和人类研究中的一些观察表明，在那些拥有现有肿瘤病灶的人中，过量摄入叶酸可能反而会产生矛盾的肿瘤发生促进作用。维生素的药物形式叶酸可能以不同于维生素天然形式的方式影响该过程，尽管这仍然是一个推测性的概念。不幸的是，我们对这种复杂关系的有限理解阻碍了广泛开展叶酸强化的努力，但这可能是必要的，以确保这些计划以安全的方式实施。
Evidence indicates that an abundant intake of foodstuffs rich in folate conveys protection against the development of colorectal cancer, and perhaps some other common cancers as well. The issue is a complex one however, since some observations in animal and human studies demonstrate that an overly abundant intake of folate among those who harbor existing foci of neoplasia might instead produce a paradoxical promotion of tumorigenesis. The pharmaceutical form of the vitamin, folic acid, might affect the process in a manner that is distinct from natural forms of the vitamin, although this remains a speculative concept. Our limited understanding of this complex relationship is unfortunately impeding efforts to move ahead with widespread folic acid fortification, but this may be necessary to ensure that such programs are instituted in a safe manner.