Staphylococcus aureus Infection of Human Gestational Membranes Induces Bacterial Biofilm Formation and Host Production of Cytokines
Staphylococcus aureus Infection of Human Gestational Membranes Induces Bacterial Biofilm Formation and Host Production of Cytokines
复制标题
DOI：
10.1093/infdis/jiw300
复制
发表时间：
2017-02-15
影响因子：
6.4
通讯作者：
Gaddy, Jennifer A.
中科院分区：
文献类型：
--
作者：
Doster, Ryan S.;Kirk, Leslie A.;Gaddy, Jennifer A.
金黄色葡萄球菌是一种代谢灵活的革兰氏阳性病原体，可引起多种组织感染。最近的证据表明S。金黄色葡萄球菌是绒毛膜炎和胎膜早破的新兴原因，与早产和新生儿疾病有关。我们证明了S.金黄色葡萄球菌感染并在破裂的人妊娠膜的绒毛膜蜕膜表面上形成生物膜。同时，S。金黄色葡萄球菌引起促炎细胞因子的产生，这最终会扰乱妊娠期间的母胎耐受。因此，针对S.妊娠期金黄色葡萄球菌感染可以减轻感染个体的疾病，特别是在抗生素耐药性的情况下。
Staphylococcus aureus, a metabolically flexible gram-positive pathogen, causes infections in a variety of tissues. Recent evidence implicates S. aureus as an emerging cause of chorioamnionitis and premature rupture of membranes, which are associated with preterm birth and neonatal disease. We demonstrate here that S. aureus infects and forms biofilms on the choriodecidual surface of explanted human gestational membranes. Concomitantly, S. aureus elicits the production of proinflammatory cytokines, which could ultimately perturb maternal-fetal tolerance during pregnancy. Therefore, targeting the immunological response to S. aureus infection during pregnancy could attenuate disease among infected individuals, especially in the context of antibiotic resistance.