"One-pot" tandem C-H borylation/1,4-conjugate addition/reduction sequence.
"One-pot" tandem C-H borylation/1,4-conjugate addition/reduction sequence.
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DOI：
10.1021/ol102518v
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发表时间：
2010-11
期刊：
影响因子：
5.2
通讯作者：
Hazmi Tajuddin;Lena Shukla;A. Maxwell;T. Marder;P. Steel
中科院分区：
文献类型：
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作者：
Hazmi Tajuddin;Lena Shukla;A. Maxwell;T. Marder;P. Steel
微波辅助的一锅法铱催化的芳香族C-H硼基化/铑催化的1，4-共轭加成序列提供了一种适用于高通量阵列合成的高度稳健的方案。通过简单地改变反应条件，可以以良好的总产率选择性地形成β-芳基取代的酮或相应的醇。
A microwave-assisted, one-pot, iridium-catalyzed aromatic C-H borylation/rhodium-catalyzed 1,4-conjugate addition sequence provides a highly robust protocol suitable for high-throughput array synthesis. Selective formation of either β-aryl-substituted ketones or the corresponding alcohols can be achieved in good overall yields by simple variation of the reaction conditions.