Measurement of endogenous nitric oxide in the lungs of patients with the acute respiratory distress syndrome
Measurement of endogenous nitric oxide in the lungs of patients with the acute respiratory distress syndrome
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DOI：
10.1164/ajrccm.157.3.9705060
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发表时间：
1998-03-01
影响因子：
24.7
通讯作者：
Evans, TW
中科院分区：
文献类型：
--
作者：
Brett, SJ;Evans, TW
在患有一些炎症性肺部疾病的患者的呼气中可以检测到一氧化氮(NO)水平的升高。我们假设，接受机械通气的急性呼吸窘迫综合征(ARDS)患者呼出的空气中可以检测到NO，而且浓度将高于接受机械通气的对照组。用化学发光法测定了13例ARDS患者和18例心脏手术前麻醉和机械通气患者下呼吸道的NO浓度。急性呼吸窘迫综合征组的NO浓度为1.13+/-0.36ppb，对照组为5.5+/-0.8ppb(P<0.0001)。急性呼吸窘迫综合征患者呼出的空气中可检测到一氧化氮，其浓度低于对照组。
Elevated levels of nitric oxide (NO) are detectable in the exhaled breath of patients suffering from a number of inflammatory lung diseases. We hypothesized that NO would be detectable in the exhaled air of patients with the acute respiratory distress syndrome (ARDS) undergoing mechanical ventilation and that the concentration would be greater than that from a control group of ventilated subjects. The concentration of NO in the lower airways of 13 patients with ARDS and 18 patients anesthetized and ventilated prior to cardiac surgery was measured by chemiluminescence. The NO concentration was 1.13 +/- 0.36 (mean +/- SEM) parts per billion (ppb) in the ARDS group and 5.5 +/- 0.8 ppb in the control group (2 p < 0.0001). NO is detectable in the exhaled air of patients with ARDS and is at a lower concentration than in control subjects.