Measurement of tone in canine colon.
Measurement of tone in canine colon.
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DOI：
10.1152/ajpgi.1991.260.3.g505
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发表时间：
1991-03
期刊：
影响因子：
--
通讯作者：
M. Neri;S. Phillips;A. Fich
中科院分区：
文献类型：
--
作者：
M. Neri;S. Phillips;A. Fich
我们试图确定近端结肠是否通过改变其壁内的音调来改变其容纳内容物的能力。在回肠末端和结肠近端装有压力记录仪的狗，将一个高度顺应的袋子引入近端结肠。使用机电恒压器，在恒定的低膨胀压力下监测结肠段的容量；气压计记录了维持袋子内预设压力所需的空气量。在禁食期间，记录有节奏的体积周期，周期频率约为1/min。重要的是，这种现象与同时记录邻近肠道的压力或回肠的消化间循环（III期）无关。回肠结区的蠕动样压力复合体（以压力计记录）与近端结肠的接受性松弛有关。喂食、乙酰胆碱和吗啡可能是通过增加结肠壁的张力而减少了袋内的容量。阿托品有相反的效果。这些结果支持了这样一个概念，即近端结肠壁上的强直性变化可能影响大肠的调节和储存，而传统技术并不总能记录下来。
We sought to determine whether the proximal colon modifies its capacity to accommodate contents by altering the tone within its wall. In dogs equipped with manometric recorders in the terminal ileum and proximal colon, a highly compliant bag was introduced into the proximal colon. With the use of an electromechanical barostat, the capacity of the colonic segment was monitored at a constant low-distending pressure; the volume of air required to maintain a preset pressure in the bag was recorded by the barostat. During fasting, rhythmic cycles of volume were recorded, with a cycle frequency of approximately 1/min. Importantly, this phenomenon was not related to the simultaneous recording of manometric pressures in the adjacent bowel or to the interdigestive cycle (phase III) in the ileum. Peristaltic-like pressure complexes (recorded manometrically) in the ileocolonic region were associated with receptive relaxation of the proximal colon. Feeding, bethanechol, and morphine reduced volumes accommodated in the bag, presumably by increasing tone in the wall of the colon. Atropine had the opposite effect. These results support the concept that tonic changes in the wall of the proximal colon, which could influence accommodation and storage in the large bowel, are not always recorded by conventional techniques.