Metastatic Tumors to the Penis: A Report of 17 Cases and Review of the Literature
Metastatic Tumors to the Penis: A Report of 17 Cases and Review of the Literature
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DOI：
10.1177/1066896909350468
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发表时间：
2011-10-01
影响因子：
1.2
通讯作者：
Young, Robert H.
中科院分区：
文献类型：
--
作者：
Chaux, Alcides;Amin, Mahul;Young, Robert H.
本研究介绍了17例阴茎转移瘤患者的临床病理和结局特征。原发部位和组织学类型如下：膀胱尿路上皮癌6例，前列腺癌4例（2例腺癌和2例腺鳞癌），结直肠腺癌2例，肺癌2例（1例鳞状细胞癌和1例小细胞癌），舌根鳞状细胞癌1例，皮肤恶性黑色素瘤1例，急性髓性白血病1例。文献回顾显示437例病例的器官部位分布相似。我们的肿瘤大多是异时性的。原发灶与阴茎转移的间隔时间3 ~ 60个月，平均16个月。大多数患者表现为阴茎肿块。4例患者出现阴茎异常勃起。最常见的解剖部位为干部（12例）。癌栓多位于勃起组织（14例），主要位于阴茎海绵体。共有14例患者死于播散性疾病。原发肿瘤和阴茎转移之间的时间间隔为3至60个月（平均19个月），阴茎转移的诊断和死亡之间的时间间隔为0.25至18个月（平均6个月），显著短（P = 0.0058）。患者的中位生存期为18个月，从初步治疗和5个月后诊断阴茎转移。死于播散性癌症的患者在病理诊断后均未存活超过18个月。临床证据表明，已知恶性肿瘤患者的阴茎受累是一个不祥的征兆，应提醒临床医生预后不良。
This study presents clinicopathologic and outcome features of 17 patients with metastatic tumor to the penis. Primary sites and histological types were as follows: 6 urothelial carcinomas of urinary bladder, 4 prostatic carcinomas (2 adenocarcinomas and 2 adenosquamous carcinomas), 2 colorectal adenocarcinomas, 2 pulmonary carcinomas (1 squamous cell carcinoma and 1 small cell carcinoma), 1 squamous cell carcinoma of base of the tongue, 1 cutaneous malignant melanoma, and 1 acute myeloid leukemia. Literature review revealed similar distribution of organ sites in 437 cases. Most of our tumors were metachronous. Interval between primary and penile metastasis ranged from 3 to 60 months (mean 16 months). Most of the patients presented with a penile mass. Priapism was observed in 4 patients. The shaft was the commonest anatomical site involved (12 cases). Tumor emboli were usually found in the erectile tissues (14 cases), mainly corpora cavernosa. A total of 14 patients died of disseminated disease. Time interval between primary tumor and penile metastasis ranged from 3 to 60 months (mean 19 months) and between diagnosis of penile metastasis and death ranged from 0.25 to 18 months (mean 6 months), significantly shorter (P = .0058). Patients presented a median survival of 18 months from primary treatment and 5 months after diagnosis of penile metastasis. None of the patients who died of disseminated cancer lived more than 18 months after pathological diagnosis. Clinical evidence of penile involvement in a patient with a known malignancy is an ominous sign and should alert the clinicians to the dismal prognosis.