No persistent T lymphocyte immunosuppression or increased mortality after measles infection: A community study from Guinea-Bissau
No persistent T lymphocyte immunosuppression or increased mortality after measles infection: A community study from Guinea-Bissau
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DOI：
10.1097/00006454-199601000-00009
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发表时间：
1996-01-01
影响因子：
3.6
通讯作者：
Whittle, H
中科院分区：
文献类型：
--
作者：
Aaby, P;Lisse, IM;Whittle, H
背景由于麻疹免疫除了降低急性麻疹感染的死亡率外，还降低了儿童的总体死亡率，因此有人认为麻疹后病例的死亡率过高，可能与麻疹感染后持续的免疫抑制有关。在1988年几内亚比绍麻疹流行后，我们检测了麻疹病例和对照组的T淋巴细胞亚群和长期生存率。我们检测了69例麻疹后2个月的儿童，其CD 4计数略高于对照组（P = 0.06）。经年龄、性别和免疫状况调整后，麻疹后病例与对照组的死亡率比为0.50（95%可信区间，0.22 ~ 1.16）（P = 0.11）。没有迹象表明麻疹感染后T细胞亚群的持续抑制，麻疹后病例的死亡率并不高于未感染的社区对照。
Background. Because measles immunization is reducing overall childhood mortality in addition to mortality from acute measles infection, it has been suggested that postmeasles cases have excess mortality, possibly related to persistent immunosuppression after measles infection. After an epidemic in 1988 in Guinea-Bissau, we there fore examined T lymphocyte subsets and long term survival among measles cases and controls,Methods. We examined 69 children 2 months after infection had slightly higher CD4 counts than controls (P = 0.06), Adjusted for age, sex and immunization status, postmeasles cases had a mortality rate ratio of 0.50 (95% confidence interval, 0.22 to 1.16) (P = 0.11) compared with controls.Conclusions. There is no indication of persistent suppression of T cell subsets after measles infection, and postmeasles cases did not have higher mortality than uninfected community controls.