Right Ventromedial and Dorsolateral Prefrontal Cortices Mediate Adaptive Decisions under Ambiguity by Integrating Choice Utility and Outcome Evaluation
Right Ventromedial and Dorsolateral Prefrontal Cortices Mediate Adaptive Decisions under Ambiguity by Integrating Choice Utility and Outcome Evaluation
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DOI：
10.1523/jneurosci.1279-09.2009
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发表时间：
2009-09-02
影响因子：
5.3
通讯作者：
Rubia, Katya
中科院分区：
文献类型：
--
作者：
Christakou, Anastasia;Brammer, Mick;Rubia, Katya
爱荷华州赌博任务（IGT）是奖励相关决策中最有影响力的行为范式之一，最值得注意的是，与腹内侧前额叶皮层功能相关。然而，IGT的表现依赖于一组复杂的认知子过程，特别是在模糊条件下将有关选择结果的信息整合到不断更新的决策策略中。这项任务的复杂性使得神经影像学研究很难理清潜在的神经认知过程。在这项研究中，我们使用功能性磁共振成像结合一种新的适应任务，这使我们能够分别检查与决策或决策结果的评估时刻相关的激活。重要的是，使用全脑回归分析与个人的表现，结合个人的选择/结果的历史，我们的目的是确定参与评估的结果，并在可用的选择选项的相对价值的渐进歧视，从而映射两个基本的认知过程，导致自适应决策的区域之间的神经重叠。我们发现，右腹内侧和背外侧前额叶皮层的激活是预测的适应性表现，在这两个歧视不利有利的决定，并确认负面的决策结果。我们认为，这两个前额叶区域通过对累积负面结果的敏感性来调节从不利选择中的转移。这些研究结果提供了功能的证据，这些前额叶子区域驱动适应性选择的任务，即通过偶然性敏感的结果评价的基本过程。
The Iowa gambling task (IGT) is one of the most influential behavioral paradigms in reward-related decision making and has been, most notably, associated with ventromedial prefrontal cortex function. However, performance in the IGT relies on a complex set of cognitive subprocesses, in particular integrating information about the outcome of choices into a continuously updated decision strategy under ambiguous conditions. The complexity of the task has made it difficult for neuroimaging studies to disentangle the underlying neurocognitive processes. In this study, we used functional magnetic resonance imaging in combination with a novel adaptation of the task, which allowed us to examine separately activation associated with the moment of decision or the evaluation of decision outcomes. Importantly, using whole-brain regression analyses with individual performance, in combination with the choice/outcome history of individual subjects, we aimed to identify the neural overlap between areas that are involved in the evaluation of outcomes and in the progressive discrimination of the relative value of available choice options, thus mapping the two fundamental cognitive processes that lead to adaptive decision making. We show that activation in right ventromedial and dorsolateral prefrontal cortex was predictive of adaptive performance, in both discriminating disadvantageous from advantageous decisions and confirming negative decision outcomes. We propose that these two prefrontal areas mediate shifting away from disadvantageous choices through their sensitivity to accumulating negative outcomes. These findings provide functional evidence of the underlying processes by which these prefrontal subregions drive adaptive choice in the task, namely through contingency-sensitive outcome evaluation.