Glycyrrhizin inhibits the lytic pathway of complement - Possible mechanism of its anti-inflammatory effect on liver cells in viral hepatitis
Glycyrrhizin inhibits the lytic pathway of complement - Possible mechanism of its anti-inflammatory effect on liver cells in viral hepatitis
复制标题
DOI：
10.1111/j.1348-0421.2000.tb02566.x
复制
发表时间：
2000-01-01
影响因子：
2.6
通讯作者：
Nishioka, K
中科院分区：
文献类型：
--
作者：
Fujisawa, Y;Sakamoto, M;Nishioka, K
甘草甜素是甘草根的水提取物，具有抗炎活性，并已用于治疗慢性病毒性肝炎。在本研究中，我们描述的机制，抑制补体。甘草酸通过激活经典和替代途径抑制补体的细胞溶解活性，而对免疫粘附没有影响，表明它阻断了C5或补体级联的后期阶段。进一步的分析表明，白藜芦醇抑制溶解途径，其中膜攻击复合物（MAC）的形成。这一机制表明，胡萝卜素可以防止MAC引起的组织损伤，不仅在慢性肝炎，但在许多自身免疫性和炎症性疾病。
Glycyrrhizin,an aqueous extract of licorice root, has anti-inflammatory activity and has been used for the treatment of chronic viral hepatitis. In the present study we describe the mechanism by which glycyrrhizin inhibits complement. Glycyrrhizin inhibited the cytolytic activity of complement via the activation of both the classical and alternative pathways, while it had no effect on immune adherence, suggesting that it blocks C5 or a later stage of the complement cascade. Further analysis revealed that glycyrrhizin inhibits the lytic pathway in which the membrane attack complex (MAC) is formed. This mechanism suggests that glycyrrhizin may prevent tissue injury caused by MAC not only in chronic hepatitis but in many autoimmune and inflammatory diseases.