Signaling on the endocytic pathway
Signaling on the endocytic pathway
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DOI：
10.1016/j.ceb.2007.04.021
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发表时间：
2007-08-01
影响因子：
7.5
通讯作者：
Sorkin, Alexander
中科院分区：
文献类型：
--
作者：
von Zastrow, Mark;Sorkin, Alexander
内吞作用通过控制细胞表面可用的功能性受体的数量来调节许多细胞信号传导过程。相反，一些信号传导过程调节内吞途径。此外，各种细胞信号传导事件似乎发生在内体膜上。内吞途径，通过提供一组动态的和生化专门的内膜结构，物理上与质膜沟通，越来越多地被视为一个高度灵活的支架，用于介导精确的时空控制和运输的各种生物信号。基于内吞体的信号传导的一般原理开始出现，但在许多情况下，内吞途径上信号传导的生理意义仍然知之甚少。
Endocytosis regulates many cellular signaling processes by controlling the number of functional receptors available at the cell surface. Conversely, some signaling processes regulate the endocytic pathway. Furthermore, various cellular signaling events appear to occur on endosome membranes. The endocytic pathway, by providing a set of dynamic and biochemically specialized endomembrane structures that physically communicate with the plasma membrane, is increasingly viewed as a highly flexible scaffold for mediating precise spatiotemporal control and transport of diverse biological signals. General principles of endosome-based signaling are beginning to emerge but, in many cases, the physiological significance of signaling on the endocytic pathway remains poorly understood.